Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohns Disease

Shiori Kinoshita, Satoshi Tanida, Akimi Kawai, Kazuhide Shiraga, Tomoyuki Nakamura, Kana Oiwa, Tomotaka Suzuki, Asahi Ito, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Shinsuke Iida


Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohns disease. The patient had been diagnosed with Crohns disease at the age of 28 years and had received conventional treatments with biologics, but not azathioprine. At the age of 51, he was diagnosed with APL with ider(17). Long-term exposure to chronic continuous inflammation from Crohns disease might be a factor inducing genomic instability in HSCs, which lead to the subsequent development of APL. APL is a rare hematological manifestation that required attention in Crohns disease patients.

J Clin Med Res. 2022;14(3):136-141


Acute promyelocytic leukemia; Crohn’s disease; Inflammatory bowel disease; Chronic inflammation; Hematopoietic stem cell; Myeloid neoplasm

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