Relationship Between Serum Total Testosterone Concentration and Augmentation Index at Radial Artery in Japanese Postmenopausal Patients

Takashi Hitsumoto


Background: The significance of testosterone as a risk factor for cardiovascular disease (CVD) in females is controversial. This cross-sectional study aimed to elucidate the relationship between serum total testosterone concentration (T-T) and augmentation index at the radial artery (r-AIx) as a marker of arterial function in Japanese postmenopausal patients.

Methods: A total of 447 postmenopausal patients with traditional cardiovascular risk factors and/or a history of CVD (age (mean standard deviation (SD)), 73 10 years) were enrolled. r-AIx was measured using tonometry, and the association between r-AIx and various clinical parameters, including T-T, was determined.

Results: r-AIx significantly increased (CVD vs. non-CVD: 9911% vs. 9111%, P < 0.001) and T-T significantly decreased (CVD vs. non-CVD: 0.31 0.13 ng/mL vs. 0.49 0.23 ng/mL, P < 0.001) in patients with CVD than in those without CVD. A significant negative correlation (r = -0.48; P < 0.001) between r-AIx and T-T was observed. Furthermore, multiple regression analysis indicated that T-T (t value = -7.7; P < 0.001), height (t value = -5.3; P < 0.001), d-ROMs test as a marker of oxidative stressin vivo (t value = 3.2; P < 0.001), CVD (t value = 2.9; P < 0.01), and pulse rate (t value = -2.7; P < 0.01) were independent variables for r-AIx as a subordinate factor.

Conclusion: This study revealed that low T-T is an important determining factor for an increase in r-AIx in Japanese postmenopausal patients. A prospective multicenter study with a large sample size is required to confirm the results of this study.

J Clin Med Res. 2017;9(10):872-878


Testosterone; Augmentation index; Oxidative stress; Cardiovascular disease; Female

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