Endothelial Lipase Plasma Levels are Increased in Patients With Significant Carotid Artery Stenosis and History of Neurological Impairment

Monika Riederer, Matias Trbušić, Vesna Degoricija, Saša Frank

Abstract


Background: Endothelial lipase (EL) is a phospholipase expressed predominantly by vascular endothelial cells. The goal of the present study was to examine whether EL plasma levels in patients with carotid artery stenosis differ between those with previous history of neurological impairment and those without neurological symptoms.  

Methods: EL plasma levels were measured by a competitive ELISA assay. 

Results: EL plasma levels were significantly higher in the symptomatic, compared with the asymptomatic group (mean 489.61 ± 145 ng/ml (n = 31) vs. 388.39 ± 133 ng/ml (n = 24), t-test, P  = 0.011).

Conclusion: We concluded that increased EL plasma levels reflect the patients' overall susceptibility for cerebrovascular events.




doi:10.4021/jocmr734w


Keywords


Atherosclerosis; Carotid artery stenosis; Endothelial lipase; Neurological impairment; Carotid endarterectomy

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