J Clin Med Res
Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website https://www.jocmr.org

Letter to the Editor

Volume 12, Number 10, October 2020, pages 681-682


De Novo Urinary Symptoms Associated With COVID-19: COVID-19-Associated Cystitis

Nivedita Dhara, b, Sorabh Dharb, c, Ryan Timarc, Steven Lucasb, c, Laura E. Lambd, e, Michael B. Chancellord, e, f

aDetroit Medical Center, Detroit, MI, USA
bJohn D. Dingell VA Medical Center, Detroit, MI, USA
cWayne State University School of Medicine, Detroit, MI, USA
dDepartment of Urology, Beaumont Health System, Royal Oak, MI, USA
eOakland University William Beaumont School of Medicine, Rochester Hills, MI, USA
fCorresponding Author: Michael B. Chancellor, Beaumont Health Research Institute, 3811 W. 13 Mile Road, Suite 504, Royal Oak, MI 48073, USA

Manuscript submitted July 21, 2020, accepted July 27, 2020, published online September 21, 2020
Short title: COVID-19-Associated Cystitis
doi: https://doi.org/10.14740/jocmr4294

To the Editor▴Top 

Clinical symptoms that present early in coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been well-reported. Although the majority number of patients develop mild symptoms, a small percentage can progressively develop acute respiratory distress syndrome and multiple organ dysfunction syndrome resulting in demise [1]. There is an emergence of new symptoms that involve many organ systems, some more subtle than others. As these symptoms may overlap with other common disease processes, it has been difficult to identify and link these symptoms as direct association with COVID-19 as the underlying cause [2].

Recently Mumm and his colleagues have reported increased urinary frequency in COVID-19 patients [3]. We noticed at our tertiary care medical center’s COVID-19 clinic that patients reported de novo urinary tract symptoms and therefore obtained institutional review board (IRB) approval for a case series. We surveyed urinary symptoms in patients who followed up in the outpatient setting after their hospitalization from COVID-19. All patients had confirmed positive SARS-CoV-2 molecular diagnostic test. Patients filled out their survey responses in the office setting. Urinary symptoms are based on a validated bladder health questionnaire (Overactive Bladder (OAB) Assessment Tool) [4]: The five individual symptom scores range from 0 to 5 based on urinary urgency, urge incontinence, incontinence, frequency, and nocturia. We noted patient’s hospital dates to establish length-of-stay (LOS) and the study was conducted from May 22 to June 26, 2020.

We identified 39 COVID-19-positive patients, including seven females and 32 males, who developed de novo urinary symptoms without urinary tract infection per standard urine culture and sensitivity testing. The patients were all outpatients post hospital discharge and did not have fever or other clinical conditions that would require inpatient health care. All patients were African American. Median LOS was 10 days (range 5 - 30). All 39 patients completed the symptom score survey. The median total OAB symptom score in men and women was 18 (ranges 12 - 20 and 15 - 21, respectively) (Table 1). Our case series bring awareness to the possibility of new onset urinary symptoms in COVID-19 patients and the cause of the symptoms remains unsolved. The most remarkable urologic complaints were increased urinary frequency of ≥ 13 episodes/24 h (85%) and nocturia ≥ four episodes/night (87%).

Table 1.
Click to view
Table 1. Demographics and Symptoms
 

In conclusion, in a limited survey of patients at a tertiary care COVID-19 clinic, we found COVID-19 patients, both men and women, may report de novo lower urinary tract symptoms. The most bothersome new urinary tract symptoms include urinary frequency and nocturia. Physicians caring for COVID-19 should be aware of COVID-19-associated cystitis (CAC).

Acknowledgments

None to declare.

Financial Disclosure

None to declare.

Conflict of Interest

The authors declare that they have no relevant conflict of interest to report.

Informed Consent

Informed consents have been obtained from the patients.

Author Contributions

MC and ND contributed to the formulation. SD, ND, LL, and MC planned the study. RT, ML, ND, and SD collected the data. LL, MC, ND, and SD analyzed the data. All authors involved in writing the manuscript.

Data Availability

The data supporting the findings of this study are available from the corresponding author upon reasonable request.


References▴Top 
  1. Wang H, Ma S. The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. Am J Emerg Med. 2008;26(6):711-715.
    doi pubmed
  2. Sighinolfi MC, Rocco B, Mussini C. COVID-19: Importance of the Awareness of the Clinical Syndrome by Urologists. Eur Urol. 2020;78(1):e40-e41.
    doi pubmed
  3. Mumm JN, Osterman A, Ruzicka M, Stihl C, Vilsmaier T, Munker D, Khatamzas E, et al. Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis? Eur Urol. 2020.
    doi pubmed
  4. Overactive Bladder Assessment Tool. 2018. https://www.urologyhealth.org/educational-materials/overactive-bladder-assessment-tool-x4801. Accessed May 1, 2020.


This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Journal of Clinical Medicine Research is published by Elmer Press Inc.



 

 

 

 

Browse  Journals  

     

Journal of clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 

 

 

 

Journal of Clinical Medicine Research, monthly, ISSN 1918-3003 (print), 1918-3011 (online), published by Elmer Press Inc.            
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jocmr.org   editorial contact: editor@jocmr.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.