Gender Differences in Cardiac Function Following Three-Month Administration of Tofogliflozin in Patients With Diabetes Mellitus

Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Shinya Yamada, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kamasaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro


Background: Patients with type 2 diabetes mellitus (T2DM) are at increased risk for impairment in heart failure and diastolic relaxation while preserving ejection fraction (EF). Recently, several sodium glucose cotransporter-2 (SGLT2) inhibitors have demonstrated to decrease cardiovascular disease (CVD) events in elderly diabetic patients, although gender difference in the effect of SGLT2 inhibitors is unknown. The objective of the present study was to evaluate gender difference in the effect of tofogliflozin, one of the SGLT2 inhibitors, on CVD function in patients with diabetes mellitus.

Methods: This was a retrospective study. Patients received 20 mg of tofogliflozin daily for 3 months. EF, ratio of early filling to atrial filling (E/A), a change in mitral inflow E and mitral e' annular velocities (E/e'), left atrial dimension (LAD) and maximal diameter of inferior vena cava (IVCmax), including various physiological parameters were measured between baseline, 1 month and 3 months after administration of tofogliflozin. Interaction between gender and time after administration was evaluated using mixed effect model.

Results: The results showed significant decrease in E/e' (P < 0.01) and significant interaction between time and gender in E/A (P < 0.01), following administration of tofogliflozin for 3 months. EF was constantly higher significantly in women (P < 0.01).

Conclusion: It is concluded that 3-month administration of tofogliflozin decreased E/e' with gender difference in EF and E/A.

J Clin Med Res. 2020;12(8):530-538


Tofogliflozin; Elderly; Diabetes mellitus; EF; E/A; E/e'

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