A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes

Masahiko Takai, Masashi Ishikawa, Hajime Maeda, Akira Kubota, Kotaro Iemitsu, Shinichi Umezawa, Takehiro Kawata, Tetsuo Takuma, Hiroshi Takeda, Keiji Tanaka, Hideo Machimura, Fuyuki Minagawa, Atsuko Mokubo, Tetsuya Motomiya, Akira Kanamori, Ikuro Matsuba


Background: There are several reports of seasonal variation in hemoglobin A1c (HbA1c) in patients with type 2 diabetes (T2DM), but no reports of seasonal variation in the effect of add-on drugs on blood glucose control in insulin-treated patients.

Methods: Using data collected from 630 patients in a multicenter study, we compared the amount of change in HbA1c after 1, 3, 6, 9, and 12 months of add-on administration of sitagliptin in insulin-treated patients divided into four groups based on the month when sitagliptin was started.

Results: A significantly larger decrease in HbA1c at 6 months from baseline was observed in the group that started add-on sitagliptin in February to April than in the other three groups. However, the amount of change in HbA1c at 12 months did not differ among the groups.

Conclusions: The consideration of seasonal variation enables more accurate evaluation of a drugs short-term effect on blood glucose control.

J Clin Med Res. 2020;12(3):200-208
doi: https://doi.org/10.14740/jocmr4103


Sitagliptin; Seasonal effect; Dipeptidyl peptidase-4 inhibitor; HbA1c; Type 2 diabetes

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