Effects of Repaglinide Versus Glimepiride on 1,5-Anhydroglucutol and Glycated Hemoglobin Levels in Japanese Patients With Type 2 Diabetes

Hodaka Yamada, Masafumi Kakei, Kazuo Hara


Background: Postprandial hyperglycemia is a well-known risk factor for cardiovascular disease. We prospectively examined the effects of repaglinide on postprandial hyperglycemia in patients with type 2 diabetes.

Methods: During this 24-week, single-arm, prospective study, we enrolled 10 patients with type 2 diabetes who were previously being administered glimepiride (0.5 or 1 mg/day) and switched it with repaglinide (0.75 or 1.5 mg/day). Changes in their metabolic parameters were evaluated at the end of the study period.

Results: After replacing glimepiride with repaglinide, increases were observed in 1,5-anhydroglucitol levels (baseline, 5.46 1.96 versus 24 weeks, 9.15 4.48 g/mL, P = 0.004) but not in glycated hemoglobin levels (baseline, 7.7 0.5 versus 24 weeks, 7.4 0.6%, P = 0.100). Body weight remained unchanged.

Conclusion: Compared with glimepiride, repaglinide improved 1,5-anhydroglucitol levels but had no effect on glycated hemoglobin. This suggests that repaglinide is a useful option for treating postprandial hyperglycemia.

J Clin Med Res. 2018;10(11):838-842
doi: https://doi.org/10.14740/jocmr3618w


Postprandial hyperglycemia; Type 2 diabetes; 1,5-anhydroglucitol; Glinide; Sulfonylurea

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