Type 2 Diabetes and Glycemic Variability: Various Parameters in Clinical Practice

Masaya Sakamoto


It has become possible to measure blood glucose levels continuously from 24 h to approximately 2 weeks due to the recent development of relevant devices such as continuous glucose monitoring and flash glucose monitoring systems. This has enabled not only medical professionals but also patients to monitor details of glycemic variability (GV) which was not possible in the past. Details of GV for both short and intermediate periods can now be obtained, and it is important in patient care to appropriately evaluate the data obtained. Types of GV in terms of time frame vary from short-term to long-term. Several studies reported that long-term GV was related to micro- and macro-angiopathies in patients with type 2 diabetes mellitus (T2DM). However, there are still unknown aspects regarding the relationships of various durations of GV with prognosis. Further clinical trials are required to examine the mechanism of GV and to evaluate whether GV can be a valuable therapeutic target in treatment of patients with T2DM.

J Clin Med Res. 2018;10(10):737-742
doi: https://doi.org/10.14740/jocmr3556w


Glycemic variability; Short-term glycemic variability; Mean of daily difference; Long-term glycemic variability; Visit-to-visit HbA1c variability; Continuous glucose monitoring; Type 2 diabetes mellitus

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