The Impact of Admission Serum Creatinine Derived Estimated Glomerular Filtration Rate on Major Adverse Cardiac Events in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

Mahmut Uluganyan, Gurkan Karaca, Turker Kemal Ulutas, Ahmet Ekmekci, Eyup Tusun, Ahmet Murat, Bayram Koroglu, Huseyin Uyarel, Nijad Bakhshaliyev, Mehmet Eren


Background: The impact of Cockroft-Gault (C-G) derived estimated glomerular filtration rate (eGFR) on mortality and major adverse cardiac events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) was assessed.

Methods: A total of 884 patients were classified into four categories according to admission creatine derived eGFR: < 60, 60 - < 90, 90 - < 120, and >= 120 mL/min/1.73 m2.

Results: In-hospital and long-term MACEs were significantly higher in eGFR < 60 mL/min/1.73 m2 subgroup (P < 0.001 and P = 0.028). Multivariate analysis demonstrated 7.78-fold (95% CI: 0.91 - 66.8) higher mortality risk in eGFR < 60 mL/min/1.73 m2 subgroup.

Conclusion: As an easily applicable bedside method, C-G derived eGFR could be important for prediction of in-hospital and long-term mortality and MACE in STEMI patients undergoing primary PCI.

J Clin Med Res. 2016;8(4):325-330


Estimated glomerular filtration rate; Cockcroft-Gault; Mortality; ST-segment elevation myocardial infarction; Major adverse cardiac events

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