Recent Patient Characteristics and Medications at Admission and Discharge in Hospitalized Patients With Heart Failure

Tadaaki Arimura, Shin-ichiro Miura, Natsumi Morito, Yuhei Shiga, Ken Kitajima, Joji Morii, Atsushi Iwata, Kanta Fujimi, Eiji Yahiro, Keijiro Saku


Background: To improve the clinical outcome of heart failure (HF), it is important to evaluate the etiology and comorbidities of HF. We previously reported the baseline clinical characteristics and medications in hospitalized patients with HF in years 2000 - 2002 (group 2000) and 2007 - 2009 (group 2008).

Methods: We conducted a retrospective study of 158 patients who were hospitalized due to HF between 2012 and 2014 (group 2013) in the Department of Cardiology, Fukuoka University Hospital. We analyzed the clinical characteristics and medications at admission and discharge, and compared the findings in group 2013 to those in group 2000 and group 2008.

Results: The major causes of HF were ischemic heart disease, hypertensive cardiomyopathy, valvular heart disease, and dilated cardiomyopathy. The New York Heart Association classification in group 2013 was significantly higher than those in group 2000 and group 2008. There was no difference in the level of brain natriuretic peptide at admission between group 2008 and group 2013. Tolvaptan began to be administered in group 2013. The median dose of furosemide just before the use of tolvaptan was 40 mg/day. At discharge, group 2013 showed higher rates of beta-blocker and aldosterone antagonist. There was no difference in the frequency of loop diuretics. The dose of carvedilol at discharge was only 6.2 4.0 mg/day. Antiarrhythmic drugs and beta-blocker were used more frequently in HF with reduced ejection fraction (EF) than in HF with preserved EF.

Conclusions: We may be able to improve the clinical outcome of HF by examining the differences in the clinical characteristics and medications at admission and discharge in hospitalized patients with HF.

J Clin Med Res. 2016;8(2):97-104


Heart failure; Clinical characteristics; β-blocker; Aldosterone antagonist; Tolvaptan

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