Does Modification to the Approach to Contacting Potential Participants Improve Recruitment to Clinical Trials?

Vinit Sawhney, Adam Graham, Niall Campbell, Richard Schilling

Abstract


Background: It is critical that clinical trial researchers ensure efficient and successful patient recruitment. Recruitment is often slower than expected and required sample sizes not obtained within initial funding deadlines. There is little rigorous evidence supporting ways to improve recruitment. We hypothesized making telephone contact with subjects prior to hospital attendance would improve recruitment rates into clinical trials.

Methods: Retrospective post hoc analysis of recruitment rates in an on-going clinical trial was undertaken. Two hundred twelve consecutive patients were recruited over 6 months. During the first 3 months, patients received a telephone call from the research team and also received an information sheet by post prior to clinic attendance (group 1). The study was discussed on telephone and any issues were re-addressed at the patient’s clinic appointment when they were formally invited to participate in the study. After 3 months, the investigators stopped telephoning the patients (group 2); patients were invited to participate in the study by post and were first spoken to directly by an investigator in clinic. The study protocol and investigators did not change between groups.

Results: There was no significant difference in baseline demographics between the two groups. There was a significant improvement in recruitment rate in group 1 compared to group 2 (77.7% vs. 45.0%, P < 0.0001). An improvement in clinic attendance rate in group 1 was observed, although this was not significant (did not attend rate: 2.9% vs. 7.8%, P = 0.14).

Conclusion: Telephone contact between researchers and potential participants prior to clinic attendance can greatly improve study recruitment rates. This information may benefit the design of all clinical studies.




J Clin Med Res. 2014;6(5):384-387
doi: http://dx.doi.org/10.14740/jocmr1879w


Keywords


Clinical trials; Patient recruitment; Telephone call 

Full Text: HTML PDF

 

 

 

 
Home     |     Log In     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


Aims and Scope

Current Issues

Conflict of Interest

About Publisher

Editorial Board

Archives

Copyright

Company Profile

Editorial Office

Misconduct and Retraction

Permissions

Company Registration

Contact Us

Abstracting and Indexing

ICMJE

Ownership

Instructions to Authors

Access

Declaration of Helsinki

Contact Publisher

Submission Checklist

Reprints

Terms of Use

Company Address

Submit a Manuscript

Open Access Policy

Privacy Policy

Browse Journals

Publishing Fee

Publishing Policy

Disclaimer

Recent Highlights

Peer-Review Process

Publishing Quality

Code of Ethics

Advertising Policy

Manuscript Tracking

Advanced Search

For Librarians

Careers

Publishing Process

Publication Frequency

For Reviewers

Propose a New Journal

       

Journal of Clinical Medicine Research, monthly, ISSN 1918-3003 (print), 1918-3011 (online), published by Elmer Press Inc.        
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jocmr.org   editorial contact: editor@jocmr.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

DECLARATION: THIS JOURNAL SITE OUTLOOK IS DESIGNED BY THE PUBLISHER AND COPYRIGHT PROTECTED. DO NOT COPY!