Near Misdiagnosis of Glioblastoma as Primary Central Nervous System Lymphoma

Vijaya Raj Bhatt, Rajesh Shrestha, Nicole Shonka, R. Gregory Bociek


Primary central nervous system (CNS) lymphoma, most frequently a diffuse large B-cell lymphoma, is a rare aggressive lymphoma confined to the CNS, thus requiring differentiation from other brain malignancies such as glioblastoma. Although stereotactic biopsy can confirm the diagnosis, this is invasive, not always feasible and can be inconclusive after steroid use. Hence, cranial magnetic resonance imaging (MRI) with contrast and cerebrospinal fluid analysis are frequently used to make a prompt diagnosis. We report a case of a woman with two brain masses who presented unique diagnostic challenge.

J Clin Med Res. 2014;6(4):299-301


Primary central nervous system lymphoma; Glioblastoma; Flow cytometry; Magnetic resonance imaging

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