A Case of Nephrotic Syndrome With Minimal-Change Disease and Waldenstroms Macroglobulinemia

Darren W. Grabe, Bo Li, Syed S. Haqqie


Kidney disease is a rare complication of Waldenstroms macroglobulinemia. We report a case of nephrotic syndrome and minimal change disease in a patient with biopsy proven Waldenstroms macroglobulinemia. The patient presented with over 12 grams of proteinuria and was successfully treated with oral prednisone over the course of 4 weeks. Repeat serum protein electrophoresis as well as serum immunoelectrophoresis revealed no paraproteins, urine analysis was negative for protein or blood by dipstick and spot urine protein was 9 mg/dL with creatinine of 101 mg/dL at time of last office visit. This case illustrates the successful treatment with corticosteroids alone with prolonged complete remission.

doi: http://dx.doi.org/10.4021/jocmr1387w


Waldenstrom’s macroglobulinemia; Nephrotic syndrome; Minimal change disease

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