Granulomas Formation in Lymph Nodes, Liver and Spleen in Adult-Onset Still’s Disease: A Case Report

Stelios F. Assimakopoulos, Vassilios Karamouzos, Christos Papakonstantinou, Vassiliki Zolota, Chryssoula Labropoulou-Karatza, Charalambos Gogos

Abstract


Tissue granulomas formation in adult-onset Still’s disease (AOSD) is extremely rare. We describe a case of AOSD associated with formation of granulomatous lesions in lymph nodes, liver and presumably spleen. The high dose steroid-dependent nature of our patient’s illness, characterized by disease relapses when methylprednisolone dose was reduced below 10 mg/d, was overwhelmed with institution of anakinra (100 mg/d). The histologic finding of granulomas formation in lymph nodes, liver or spleen should not deter the consideration of AOSD as a potential diagnosis in a compatible clinical context; however, other more common etiologies of tissue granulomas formation should be first excluded.




doi: http://dx.doi.org/10.4021/jocmr1281e

Keywords


Adult-onset Still’s disease; Granulomatous; Lymphadenitis; Hepatic granulomas; Anakinra

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