Journal of Clinical Medicine Research

Editor-in-Chief: Kei Nakajima, Professor, MD, PhD, School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Kanagawa, Japan
Frequency: Monthly
Journal Access: Open Access
ISSN-print: 1918-3003
ISSN-online: 1918-3011
Journal scope: Multi-discipline of clinical medicine, medical research and clinical practice, preventive medicine, epidemiology, nursing, and healthcare research, clinically focused, evidence-based medicine.
Indexed and covered: PubMed, PubMed Central, Chemical Abstract (CA), EBSCO, Worldcat, JournalTOCs, Google, Google Scholar, Clarivate Analytics Links- Journal Title List.

Journal archiving and digital preservation:


  • Management of Esophageal Achalasia in Quebec

    Esophageal achalasia is a defective relaxation of the lower esophageal sphincter with a loss of esophageal peristalsis causing dysphagia. Treatment can be Heller myotomy, pneumatic balloon dilation, Botox injections, peroral endoscopic myotomy (POEM) or medical. The main objective of the study was to measure the extent of post-treatment dysphagia depending on the type of treatment.

  • Does Red Cell Distribution Width Predict Outcome in Traumatic Brain Injury: Comparison to Corticosteroid Randomization After Significant Head Injury

    Traumatic brain injury (TBI) is a leading cause of death and disability. The role of red cell distribution width (RDW) as a prognostic biomarker for outcome in TBI patients is unknown. Based on the corticosteroid randomization after significant head injury (CRASH) trial database, a prognosis calculator (CRASH) has been developed for outcome prediction in TBI.

  • A Multiple Treatment Comparison of Eleven Disease-Modifying Drugs Used for Multiple Sclerosis

    Several disease-modifying drug therapies are available for the treatment of multiple sclerosis (MS). To ensure the most appropriate MS management, we assessed the effectiveness and cost-effectiveness of the disease-modifying medicines used for MS.

  • Pancreatic Involvement in Inflammatory Bowel Disease

    Inflammatory bowel disease (IBD) is a multisystemic disease, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases in Crohn’s disease and ulcerative colitis is more frequent compared to the general population.

  • Bi-Luminal Mitral Valve: Incidence, Clinical Features, Associated Anomaly and Echocardiographic Evaluation

    The aim of the study was to know the incidence, clinical features, associated anomaly and echocardiographic evaluation of bi-luminal mitral valve (also known as double orifice mitral valve or DOMV) in patients with suspected mitral valve disease, continous murmur or left-to-right shunt.

  • Assessment of Salivary Nitric Oxide Levels in Elite University Athletes in Japan: Findings From a Cross Sectional Study Design

    High-intensity exercise affects the level of salivary nitric oxide (NO) with an impact on oxidative stress such as a reactive nitrogen-oxide species. However, in athletes with high-intensity training, the relationship between salivary NO levels and oxidative stress is yet to be clear. Additionally, the association of salivary NO levels and the common health disorders of athletes is unknown.







Influence of the Lung Microbiota Dysbiosis in Chronic Obstructive Pulmonary Disease Exacerbations: The Controversial Use of Corticosteroid and Antibiotic Treatments and the Role of Eosinophils as a Disease Marker
Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease associated with loss of lung function, poorer quality of life, co-morbidities, significant mortality, and higher health care costs. Frequent acute exacerbations of COPD are sudden worsening of symptoms, the nature of which is associated with bacterial or viral infections. Full Text

Ezetimibe Monotherapy Reduces Serum Levels of Platelet-Activating Factor Acetylhydrolase in Patients With Dyslipidemia
The combination of ezetimibe with statin therapy reduced cardiovascular events compared to statin monotherapy in IMPROVEIT study, and ezetimibe monotherapy attenuated atherosclerosis in basic study. We previously showed ezetimibe monotherapy was especially effective for metabolic syndrome (MetS) patients. We investigated the effects of ezetimibe monotherapy for high-density lipoprotein cholesterol (HDL-chol) function and platelet-activating factor acetylhydrolase (PAF-AH) activity. Full Text

Image of the Issue

Massive Hemoptysis Due to the Rupture of Thoracic Aortic Aneurysm Caused by Leukemic Cell Infiltration in a Patient With Chronic Myelomonocytic Leukemia
Hemoptysis is occasionally experienced in patients with hematological malignancies who have respiratory tract infection and severe thrombocytopenia. Thrombocytopenia due to hematological disease is one cause of hemoptysis. Full Text

Video Report

Isolated Right Ventricular Dilated Cardiomyopathy: An Early Diagnosis
Because of an incomplete right bundle branch block, a severe right ventricular dilatation with no left ventricular cardiomyopathy was found in a 44-year-old man. Magnetic resonance and transesophageal echocardiography confirmed the finding and these tests also failed to find any potential cause. A pulmonary hemodynamic study and a coronary angiography were strictly normal. Full Text

Current Issue

Past Issues

Vol. 11, No. 10, Oct 2019

Table of Contents


Influence of the Lung Microbiota Dysbiosis in Chronic Obstructive Pulmonary Disease Exacerbations: The Controversial Use of Corticosteroid and Antibiotic Treatments and the Role of Eosinophils as a Disease Marker Abstract HTML PDF
Domenico Maurizio Toraldo, Luana Conte 667-675

Original Article

Ezetimibe Monotherapy Reduces Serum Levels of Platelet-Activating Factor Acetylhydrolase in Patients With Dyslipidemia Abstract HTML PDF
Kanako Tano, Yasunori Suematsu, Kohei Tashiro, Naoko Kumagai-Koyanagi, Yoshino Matsuo, Takashi Kuwano, Shin-ichiro Miura, Zenith Trial Investigators 676-681
Management of Esophageal Achalasia in Quebec Abstract HTML PDF
Catherine Pouyez, Elissaveta Neshkova, Daniel von Renteln, Mickael Bouin 682-689
Half Dose Once-Daily Pemafibrate Effectively Improved Hypertriglyceridemia in Real Practice Abstract HTML PDF
Chie Iitake, Kazuhiro Iitake 690-695
Is Bedside End-Tidal CO2 Measurement a Screening Tool to Exclude Pulmonary Embolism in Emergency Department? Abstract HTML PDF
Metin Ozdemir, Bedriye Muge Sonmez, Fevzi Yilmaz, Aykut Yilmaz, Murat Duyan, Seval Komut 696-702
Assessment of the Correlation Between Mother and Child Body Mass Index and Mother and Child Diet in Children With Food Allergies Abstract HTML PDF
Yasuko Fukuda, Makoto Kameda 703-710
Efficacy of Physical Activity in Prevention of Muscle Weakness in Patients With Chronic Liver Disease Abstract HTML PDF
Kazuki Ohashi, Toru Ishikawa, Asami Hoshii, Tamaki Hokari, Mitsuyuki Suzuki, Yuta Mitobe, Etsuko Yamada, Hansani Madushika Abeywickrama, Yuko Kikuchi, Hirohito Noguchi, Hiroshi Hirosawa, Yu Koyama 711-719

Short Communication

Acute Kidney Injury-Associated Systemic Inflammation Is Aggravated in Insulin-Dependent Diabetes Mellitus Abstract HTML PDF
Daniel Patschan, Katrin Schwarze, Elvira Henze, Johanna Charlotte Hoffmann, Susann Patschan, Oliver Ritter, Gerhard Anton Muller 720-724




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Journal of Clinical Medicine Research, monthly, ISSN 1918-3003 (print), 1918-3011 (online), published by Elmer Press Inc.        
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