Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 5, Number 4, August 2013, pages 286-293


An Observational Retrospective Study Provide Information on Hospitalization and Severe Outcomes of the 2009 A(H1N1) Infection in Italy

Figure

Figure 1.
Figure 1. Week distribution of hospitalized patients with suspected influenza infection and of patients with laboratory confirmed 2009 pandemic A(H1N1) virus infection (July 2009 - March 2010).

Tables

Table 1. Incidence of Hospitalization, ICU Admission and Fatal Outcomes in the 141 Patients With 2009 Pandemic A(H1N1) Laboratory Confirmed Infection
 
Age group (years)Population (n)Hospital admitted n (%)Incidence per 100,000 inhabitantsICU admittedIncidence per 100,000 inhabitantsDeathIncidence per 100,000 inhabitants
0 - 17136,56347 (33)34.410.700
18 - 64589,59263 (45)10.781.420.3
≥ 65225,51431 (22)13.752.241.8
Total951,669141 (100)14.8141.560.6

 

Table 2. Demographic Characteristics and Comorbidities of Hospitalized Patients With A(H1N1) Laboratory Confirmed Infection and Comparison of Patients in GMW and in ICU
 
Hospitalized (n = 141)GMW* (n = 127)ICU** (n = 14)ICU vs GMW
P value
GMW: General Medical Ward; ICU: Intensive Care Unit; a: More than one possible medical condition per patient; b: From either medication or immune disorders; c: Calculated as percentages of pregnancy considering the 25 fertile women (15 - 44 years).
Age, mean (range)37 (1 m - 93 y)35 (1 m - 93 y)54 (1 m - 83 y)0.022
Female66 (47%)60 (47%)6 (43%)0.755
Comorbidities n (%)a
  Any comorbidity78 (55)66 (52)12 (86)0.016
  Respiratory diseases18 (13)15 (12)3 (21)0.306
  Asthma5 (4)5 (4)0 (0)0.450
  Diabetes21 (15)17 (13)4 (29)0.130
  Cardiovascular diseases33 (23)26 (20)7( 50)0.013
  Renal diseases2 (1)1 (1)1 (7)0.056
  Neurological diseases16 (11)11 (9)5 (36)0.002
  Immuno compromisedb12 (9)8 (6)4 (29)0.005
  Pregnancyc8/25 (32)7/22 (32)1/3 (33)0.5439

 

Table 3. Symptoms and Laboratory Findings at Hospital Admission, Clinical Course and Outcome in Hospitalized Patients With A(H1N1) Laboratory Confirmed Infection and Comparison of Patients in GMW and in ICU
 
Hospitalized
(n = 141)
GMW
(n = 127)
ICU
(n = 14)
ICU vs GMW
P value
Symptoms n (%)
  Fever137 (97)124 (98)13 (93)0.307
  Myalgia40 (28)38 (30)2 (14)0.218
  Cough110 (78)100 (79)10 (71)0.167
  Headache37 (26)35 (28)2 (14)0.284
  Nasal congestion29 (21)28 (22)1 (7)0.190
  Rhinorrhea19 (13)17 (13)2 (14)0.925
  Sore throat52 (37)51 (40)1 (7)0.015
  Respiratory distress46 (33)37 (29)9 (64)0.008
  Diarrhea19 (13)14 (11)5 (36)0.010
  Abdominal pain or vomiting26 (18)24 (19)2 (14)0.673
Radiological and Laboratory findings n (%)
  Pneumonia seen on chest radiography54/110 (49)42/96 (44)12/14 (86)0.003
  Anemia81 (57)70 (55)11 (79)0.092
  Leukocytosis50 (35)42 (33)8 (57)0.074
  Leukopenia33 (23)28 (22)5 (36)0.252
  Thrombocytosis19 (13)16 (13)3 (21)0.358
  Thrombocytopenia13 (9)9 (7)4 (29)0.008
  Transaminase alteration39 (28)31 (24)8 (57)0.009
  Cpk* alteration21 (15)16 (13)5 (36)0.021
Pharmacological treatment n (%)
  Antiviral66 (47)52 (41)14 (100)0.000
  Antibiotic116 (82)102 (80)14 (100)0.067
  Corticosteroid23 (16)20 (16)3 (21)0.585
Course mean days (range)
  Interval from onset of illness to hospital admission3 (0-14)3 (0-14)3 (0-9)0.855
  Hospital stay9 (1-69)8 (1-69)19 (3-59)0.000
Outcome n (%)
  Survived135 (96)127 (100)8 (57)0.000
  Expired6 (4)06 (43)0.000