J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 4, Number 3, June 2012, pages 161-166

The Correlation Between Small Dense LDL and Reactive Oxygen Metabolites in a Physical Activity Intervention in Hyperlipidemic Subjects

**Table 1.** Measured Variables at the Pre- and Post-Intervention Examinations of Physical Activity in Hyperlipidemic Subjects
Variable	Pre-intervention	Post-intervention	P-value
LDL: low-density lipoprotein, HDL: high-density lipoprotein, d-ROMs: diacron reactive oxygen metabolites. The data are shown as the means ± standard deviation or medians (interquartile range). A paired t-test was used to analyse the respective markers. Significance level: * P ≤ 0.05, ** P ≤ 0.01.
Age, years	64 ± 6	-
Male/female, number	12/18	-
Body mass index, kg/m²	23.5 ± 3.0	23.1 ± 2.7	0.01**
Systolic blood pressure, mmHg	139 ± 19	138 ± 21	0.79
Diastolic blood pressure, mmHg	77 ± 12	79 ± 15	0.32
Fasting plasma glucose, mmol/L	5.47 ± 0.82	5.37 ± 0.73	0.28
LDL-cholesterol, mmol/L	3.83 ± 0.50	3.44 ± 0.62	0.01**
Triglycerides, mmol/L	1.24 (0.99-1.53)	1.20 (0.82-1.41)	0.17
HDL-cholesterol, mmol/L	1.76 ± 0.40	1.78 ± 0.41	0.74
Mean LDL particle size, nm	26.9 ± 0.3	27.1 ± 0.4	0.01**
d-ROMs, U. Curr.	319 ± 77	290 ± 73	0.02**

Table 1. Measured Variables at the Pre- and Post-Intervention Examinations of Physical Activity in Hyperlipidemic Subjects

Variable

Pre-intervention

Post-intervention

P-value

LDL: low-density lipoprotein, HDL: high-density lipoprotein, d-ROMs: diacron reactive oxygen metabolites. The data are shown as the means ± standard deviation or medians (interquartile range). A paired t-test was used to analyse the respective markers. Significance level: * P ≤ 0.05, ** P ≤ 0.01.

Age, years

64 ± 6

Male/female, number

12/18

Body mass index, kg/m²

23.5 ± 3.0

23.1 ± 2.7

0.01**

Systolic blood pressure, mmHg

139 ± 19

138 ± 21

0.79

Diastolic blood pressure, mmHg

77 ± 12

79 ± 15

0.32

Fasting plasma glucose, mmol/L

5.47 ± 0.82

5.37 ± 0.73

0.28

LDL-cholesterol, mmol/L

3.83 ± 0.50

3.44 ± 0.62

0.01**

Triglycerides, mmol/L

1.24 (0.99-1.53)

1.20 (0.82-1.41)

0.17

HDL-cholesterol, mmol/L

1.76 ± 0.40

1.78 ± 0.41

0.74

Mean LDL particle size, nm

26.9 ± 0.3

27.1 ± 0.4

0.01**

d-ROMs, U. Curr.

319 ± 77

290 ± 73

0.02**

**Table 2.** The Correlations of the Changes in the D-ROMs With Other Atherosclerotic Risk Variables, Including the Mean LDL Particle Size, in Hyperlipidemic Subjects
Variables	γ (P-value)	β (P-value)
d-ROMs: diacron reactive oxygen metabolites, LDL: low-density lipoprotein, HDL: high-density lipoprotein; r: simple correlation coefficient between the changes of the d-ROMs and another variable, β: stepwise multiple regression coefficient of the change of the d-ROMs with another variable after adjusting for all the listed variables. The triglycerides values were log-transformed for the analyses. Significance level: P ≤ 0.05, *P ≤ 0.01.
Age, years	-0.17 (0.38)	-0.34 (0.05)*
Gender, male	0.05 (0.81)	Not extracted
Δ Body mass index, kg/m²	0.40 (0.03)*	Not extracted
Δ Systolic blood pressure, mmHg	-0.34 (0.07)	Not extracted
Δ Diastolic blood pressure, mmHg	-0.17 (0.37)	Not extracted
Δ Fasting plasma glucose, mmol/L	0.13 (0.50)	Not extracted
Δ LDL-cholesterol, mmol/L	0.24 (0.21)	Not extracted
Δ Tyiglecerides, mmol/L	0.38 (0.04)*	Not extracted
Δ HDL-cholesterol, mmol/L	-0.25 (0.19)	Not extracted
Δ mean LDL particle size, nm	-0.44 (0.02)*	-0.55(0.01)**

Table 2. The Correlations of the Changes in the D-ROMs With Other Atherosclerotic Risk Variables, Including the Mean LDL Particle Size, in Hyperlipidemic Subjects

Variables

γ (P-value)

β (P-value)

d-ROMs: diacron reactive oxygen metabolites, LDL: low-density lipoprotein, HDL: high-density lipoprotein; r: simple correlation coefficient between the changes of the d-ROMs and another variable, β: stepwise multiple regression coefficient of the change of the d-ROMs with another variable after adjusting for all the listed variables. The triglycerides values were log-transformed for the analyses. Significance level: *P ≤ 0.05, **P ≤ 0.01.

Age, years

-0.17 (0.38)

-0.34 (0.05)*

Gender, male

0.05 (0.81)

Not extracted

Δ Body mass index, kg/m²

0.40 (0.03)*

Not extracted

Δ Systolic blood pressure, mmHg

-0.34 (0.07)

Not extracted

Δ Diastolic blood pressure, mmHg

-0.17 (0.37)

Not extracted

Δ Fasting plasma glucose, mmol/L

0.13 (0.50)

Not extracted

Δ LDL-cholesterol, mmol/L

0.24 (0.21)

Not extracted

Δ Tyiglecerides, mmol/L

0.38 (0.04)*

Not extracted

Δ HDL-cholesterol, mmol/L

-0.25 (0.19)

Not extracted

Δ mean LDL particle size, nm

-0.44 (0.02)*

-0.55(0.01)**