J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Review

Volume 4, Number 1, February 2012, pages 1-6

Effects of Antibiotics on Dental Implants: A Review

**Table 1.** Patients Data from Liturature
Primary author	# of patients	# of implants	Intervention	Other allowed interventions	Implant survival (following 3 months)
Binahmed¹⁹	125	445	1 hour post-op: 1,000,000 units penicillin	0.12% chlorhexidine pre-	445/445
intravenous or equivalent oral doses of	and postoperative mouth rinses
penicillin V or 600 mg clindamycin orally
Binahmed¹⁹	90	302	Post-op: 300 mg penicillin V orally 4 times a day,	0.12% chlorhexidine pre- and postoperative mouth rinses	301/302
or in the case of penicillin allergy, 150 mg clindamycin
orally 3 times a day for 7 days
Gynther²⁰	147	790	Pre-op + post-op: 1g oral	5 mL mouth rinse of povidone-iodine solution (73 mg/mL) was given immediately preoperatively	741/790
phenoymethyl, 1hr pre-op, and every 8 hrs post-op
Gynther²⁰	132	664	No antibiotics	5 mL rinse of povidone-iodine	630/664
solution immediately preoperatively
Laskin¹²	387	1743	Pre-op:Cephalosporin (13% of implants)	0.12% chlorhexidine	1662/1743
Erythromycin (7% of implants) Penicillin (69% of implants)
Other (10% of implants)
Laskin¹²	315	1287	No antibiotics	0.12% chlorhexidine	1158/1287
Morris²¹	Not stated	1175	Pre-op: Peterson¹, AHA (1990)²², AHA (1997)²⁵	Not stated	1131/1175
Morris²¹	Not stated	354	No antibiotics	Not stated	337/354
Kashani²²	868	2236	Post-op: 2 g phenoxymethyl	Not stated	2177/2236
penicillin twice daily for 1 week
Kashan²²	868	785	Pre-op + Post-op: 2g phenoxymethyl penicillin	Not stated	777/785
1 hour pre-op and one dose post-op the same day
Wagenberg²³	891	1561	Pre-op + Post-op: Amoxicillin (500 mg 4 times daily)	0.12% cholorhexidine	1515/1561
2 days pre-op 10 days post-op	3 times daily post-op
Wagenberg²³	891	364	Pre-op + Post-op: Clindamycin	0.12% cholorhexidine 3 times daily post-op	333/364
(300 mg 4 times daily) 2 pre-op, 10 days post-op

Table 1. Patients Data from Liturature

Primary author

# of patients

# of implants

Intervention

Other allowed interventions

Implant survival (following 3 months)

Binahmed¹⁹

125

445

1 hour post-op: 1,000,000 units penicillin

0.12% chlorhexidine pre-

445/445

intravenous or equivalent oral doses of

and postoperative mouth rinses

penicillin V or 600 mg clindamycin orally

Binahmed¹⁹

302

Post-op: 300 mg penicillin V orally 4 times a day,

0.12% chlorhexidine pre- and postoperative mouth rinses

301/302

or in the case of penicillin allergy, 150 mg clindamycin

orally 3 times a day for 7 days

Gynther²⁰

147

790

Pre-op + post-op: 1g oral

5 mL mouth rinse of povidone-iodine solution (73 mg/mL) was given immediately preoperatively

741/790

phenoymethyl, 1hr pre-op, and every 8 hrs post-op

Gynther²⁰

132

664

No antibiotics

5 mL rinse of povidone-iodine

630/664

solution immediately preoperatively

Laskin¹²

387

1743

Pre-op:Cephalosporin (13% of implants)

0.12% chlorhexidine

1662/1743

Erythromycin (7% of implants) Penicillin (69% of implants)

Other (10% of implants)

Laskin¹²

315

1287

No antibiotics

0.12% chlorhexidine

1158/1287

Morris²¹

Not stated

1175

Pre-op: Peterson¹, AHA (1990)²², AHA (1997)²⁵

Not stated

1131/1175

Morris²¹

Not stated

354

No antibiotics

Not stated

337/354

Kashani²²

868

2236

Post-op: 2 g phenoxymethyl

Not stated

2177/2236

penicillin twice daily for 1 week

Kashan²²

868

785

Pre-op + Post-op: 2g phenoxymethyl penicillin

Not stated

777/785

1 hour pre-op and one dose post-op the same day

Wagenberg²³

891

1561

Pre-op + Post-op: Amoxicillin (500 mg 4 times daily)

0.12% cholorhexidine

1515/1561

2 days pre-op 10 days post-op

3 times daily post-op

Wagenberg²³

891

364

Pre-op + Post-op: Clindamycin

0.12% cholorhexidine 3 times daily post-op

333/364

(300 mg 4 times daily) 2 pre-op, 10 days post-op

**Table 2.** Post-op Success Rates
Prophylactic regimen	Number of implants	Success rate
No antibiotic	2305	2125/2305 = 92 %
Pre-op antibiotic	3363	3238/3363 = 96%
Post-op antibiotic	2236	2177/2236 = 97%
Both pre and post-op antibiotic	3500	3366/3500 = 96%

Table 2. Post-op Success Rates

Prophylactic regimen

Number of implants

Success rate

No antibiotic

2305

2125/2305 = 92 %

Pre-op antibiotic

3363

3238/3363 = 96%

Post-op antibiotic

2236

2177/2236 = 97%

Both pre and post-op antibiotic

3500

3366/3500 = 96%

**Table 3.** The Overall Success Rate of Implants
	Total case success with antibiotics used	Total case success with no antibiotics used	Average comparison between success rates
Success rate of antibiotic use vs no use	8783/9101	2125/2305	Antibiotics: 96.5% No Antibiotics: 92%

Table 3. The Overall Success Rate of Implants

Total case success with antibiotics used

Total case success with no antibiotics used

Average comparison between success rates

Success rate of antibiotic use vs no use

8783/9101

2125/2305

Antibiotics: 96.5%
No Antibiotics: 92%