J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 3, Number 3, June 2011, pages 106-110

In Vitro Activity of Carbapenems Alone and in Combination With Amikacin Against KPC-Producing Klebsiella Pneumoniae

Figure

Figure 1.. Time-kill studies of carbapenems and amikacin alone and in combination against four KPC-3-producing K. pneumoniae isolates. GC: Growth control; AMK: amikacin; ETP: ertapenem; IPM: imipenem; MEM: meropenem.

Table

**Table 1.** Change in Colony Count (log₁₀10 CFU/mL) at 24 Hours Compared to Initial Inoculums for KPC-3-Producing *K. Pneumoniae* Isolates Using Time-Kill Methodology
Antibiotic	C16	C17	C38	C50
Synergy denoted as *.AMK: amikacin; ETP: ertapenem; IPM: imipenem; MEM: meropenem.
Growth control	5.05	4.13	4.78	4.55
AMK	1.36	3.75	2.98	4.23
ETP	4.00	3.14	5.16	4.83
IPM	4.02	3.30	4.50	4.71
MEM	3.69	3.59	4.90	4.09
ETP + AMK	1.57	2.81	3.86	4.45
IPM + AMK	-1.48*	-0.05*	-2.13*	-3.53*
MEM + AMK	-1.71*	-2.61*	-3.58*	-3.07*