| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website https://www.jocmr.org |
Review
Volume 16, Number 4, April 2024, pages 133-137
The Determinants of Eosinophilia in Patients With Severe Asthma
Tables
| Variable | N = 2,646 | Asthma with eosinophilia (n = 882) | Asthma without eosinophilia (n = 1,764) |
|---|---|---|---|
| SD: standard deviation. | |||
| Age, years, mean ± SD | 48 ± 21 | 48 ± 21 | 48 ± 21 |
| Sex, female, n (%) | 1,562 (59%) | 514 (58.3) | 1,048 (59.4) |
| White, n (%) | 1,490 (56%) | 480 (54.4) | 1,010 (57.3) |
| Black, n (%) | 568 (21%) | 192 (21.8) | 376 (21.3) |
| Hispanic, n (%) | 404 (15%) | 139 (15.8) | 265 (15.0) |
| Current smokers | 277 (10%) | 101 (11.5) | 176 (10.0) |
| Obesity | 504 (19%) | 182 (20.6) | 322 (18.3) |
| Outcomes | Asthma with eosinophilia (n = 882) | Asthma without eosinophilia (n = 1,764) | P value |
|---|---|---|---|
| GERD: gastroesophageal reflux disease; IQR: interquartile range; NSAIDs: non-steroidal anti-inflammatory drugs. | |||
| Chronic steroid use | 161 (18.3) | 168 (9.5) | < 0.001 |
| Status asthmaticus | 92 (10.4) | 131 (7.4) | 0.009 |
| Family history of asthma | 39 (4.4) | 42 (2.4) | 0.004 |
| Allergies | 183 (20.7) | 304 (17.2) | 0.028 |
| Allergy to NSAIDs | 22 (2.5) | 28 (1.6) | 0.106 |
| Nasal polyps | 17 (1.9) | 1 (0.1) | < 0.001 |
| Allergic rhinitis | 35 (4.0) | 22 (1.2) | < 0.001 |
| Allergic dermatitis | 33 (3.7) | 7 (0.4) | < 0.001 |
| Mechanical ventilation | 55 (6.2) | 60 (3.4) | < 0.001 |
| Oxygen supplementation | 114 (12.9) | 108 (6.1) | < 0.001 |
| GERD | 206 (23.4) | 368 (20.9) | 0.142 |
| In-hospital mortality, n (%) | 7 (0.8) | 21 (1.2) | 0.347 |
| Hospital length of stay, days, median (IQR) | 3 (2 - 6) | 3 (2 - 5) | < 0.001 |