Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Original Article

Volume 14, Number 8, August 2022, pages 309-314

Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases


Table 1. Autoimmune and Other Immunopathological Diseases Observed in Our Narcolepsy Type 1 Series (N = 158) and Their Prevalence in Spain (2020)
Previous (2014 - 2015)New (2020)Frequency (%)Prevalence in Spain (2020)
Autoimmune diseases
  Multiple sclerosis (MS)1-0.6365/100,000 [8]
  Systemic lupus erythematosus (SLE)1-0.6340 - 50/100,000 [9]
  Idiopathic thrombocytopenic purpura (ITP)1-0.63Unknown
  Psoriasis233.162.3% [10]
  Crohn’s disease2-1.261.9/100,000 [11]
  Ulcerative colitis1-0.638/100,000 [12]
  Multinodular goiter autoimmune (MNGA)1-0.630.8-6.4% (by sex) [13]
  Autoimmune thyroid disease (Hashimoto)211.89Up to 33% in > 70 years [14]
  Celiac disease1-0.630.27% [15]
  Type B insulin resistance syndrome (IRS-B)1-0.63Unknown
  Idiopathic recurrent facial palsy (IRFP)1-0.63Unknown
  Peyronie’s disease1-0.63Unknown
  Antiphospholipid syndrome111.26Unknown
  Rheumatoid arthritis-21,260.3-1.6% [16]
  Granuloma annulare-10.63Unknown
  Primary biliary cirrhosis-10.630.023% (Madrid) [17]
  Transverse myelitis-10.63Unknown
  Alopecia areata-10.63Unknown
Other immunopathological diseases
  Allergic rhinitis12510.75Unknown
  Allergic asthma (extrinsic)614.433-7% [18]
  Atopic dermatitis413.162-14% [19]
  Food allergy312.531-3% [20]
  Contact dermatitis (heavy metals, animals)111.262-11% (nickel) [21]
  Drug allergy-31.89Unknown