Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Original Article

Volume 13, Number 8, August 2021, pages 413-419

Effects of Age on Esophageal Motility: A High-Resolution Manometry Study


Figure 1.
Figure 1. Study flow diagram.
Figure 2.
Figure 2. Change in integrated relaxation pressure (IRP) (mm Hg) according to patient age (years).
Figure 3.
Figure 3. Change in distal contractal integral (DCI) (mm according to patient age (years).
Figure 4.
Figure 4. Change in distal latency (DL) (s) according to patient age (years).


Table 1. Patient Characteristics
IQR: interquartile range; BMI: body mass index; GERD: gastroesophageal reflux disease; NSAID: non-steroidal anti-inflammatory drug; CCB: calcium channel blocker; PPI: proton pump inhibitor; BB: beta-blocker.
Total patients (n)722
Female (%)63.8
Age (years), median (IQR)56 (46 - 66)
BMI (kg/m2), median (no. of patients with data available)25.8 (22.7 - 29.4) (274)
Manometry indication (%)
  Chest pain11.5
  Not specified6.8
Habitus (%) (no. of patients with data available)
  Smoking15.4 (369)
  Alcohol consumption33.6 (366)
Medication (%) (no. of patients with data available)
  NSAID16.6 (453)
  CCB9.1 (448)
  Opioid4.7 (449)
  PPI55.6 (446)
  BB9.8 (447)
Past medical history (%) (no. of patients with data available)
  Scleroderma0.6 (451)
  Neurological3.8 (451)
  Connective tissue disease2.6 (452)


Table 2. Multiple Linear Regression Model for IRP
CovariatesCoefficient (95% CI)P-value
IRP: integrated relaxation pressure; CI: confidence interval; BMI: body mass index; NSAID: non-steroidal anti-inflammatory drug.
Age0.08 (0.05 to 0.10)< 0.001
BMI-0.14 (-0.23 to -0.05)0.004
NSAID-1.22 (-2.42 to -0.13)0.048
Female sex0.67 (-0.02 to 1.37)0.058