Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website https://www.jocmr.org

Original Article

Volume 13, Number 7, July 2021, pages 387-391

Body Muscle-to-Fat Ratio, Rather Than Fat-to-Muscle Ratio, Significantly Correlates With Measured Insulin Resistance in Patients With Type 2 Diabetes Mellitus

Figures

Figure 1.
Figure 1. Relationship between body muscle percentage and body fat percentage and M/I. (a) Body muscle percentage was significantly related to M/I value (B = 0.71, P < 0.001), whereas (b) body fat percentage was significantly and negatively related to M/I (B = -0.72, P < 0.001). Among body fat percentages, the reciprocal approximation curve (red line; R2 = 0.61) fits better than the approximate line (black line; R2 = 0.43) against M/I values.
Figure 2.
Figure 2. Relationship between body muscle-to-fat ratio (BMFR) and fat-to-muscle ratio (FMR) and M/I. (a) BMFR was significantly related to M/I (B = 0.76, P < 0.001), whereas (b) FMR was significantly and negatively related to M/I (B = -0.60, P < 0.001).

Table

Table 1. Background Clinical Characteristics of the Study Subjects (N = 118)
 
Variables
BMI: body mass index; BMFR: body muscle-to-fat ratio; FMR: fat-to-muscle ratio; HOMA-IR: homeostasis model assessment for insulin resistance; HOMA-β: homeostasis model assessment for β cell function; eGFR: estimated glomerular filtration rate; HDL: high-density lipoprotein; LDL: low-density lipoprotein.
Male (%)75 (63.6%)
Age (years)56.6 ± 12.6
Height (cm)163.4 ± 9.2
Weight (kg)67.0 (55.5 - 76.9)
Muscle quantity (kg)45.9 ± 9.9
Body fat quantity (kg)19.1 (13.2 - 25.9)
BMI (kg/m2)24.7 (21.4 - 28.6)
Body fat percentage (%)29.0 ± 9.6
Waist circumference (cm)90.2 ± 13.8
BMFR2.62 (1.75 - 3.26)
FMR0.38 (0.30 - 0.54)
Hemoglobin A1c (%)8.6 (7.0 - 11.0)
Hemoglobin A1c (mmol/mol)70 (52 - 96)
Fasting plasma glucose (mg/dL)154 (125 - 209)
Fasting blood insulin (µU/mL)5.4 (3.4 - 7.9)
HOMA-IR2.17 (1.22 - 3.17)
HOMA-β (%)17.3 (9.4 - 30.3)
Total cholesterol (mg/dl)204 (176 - 228)
HDL-cholesterol (mg/dL)49 (41 - 57)
LDL-cholesterol (mg/dL)132.0 ± 34.2
Triglycerides (mg/dL)111 (71 - 167)
eGFR (mL/min/1.73 m2)74.9 ± 17.5
Current smoking (%)33 (28.0)
Drinking (%)32 (27.1)