| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 11, Number 11, November 2019, pages 760-763
Intravenous Immunoglobulins as Adjunct Treatment to Phototherapy in Isoimmune Hemolytic Disease of the Newborn: A Retrospective Case-Control Study
Tables
| Characteristics | IVIG group (n = 94) | Phototherapy group (n = 108) | P value |
|---|---|---|---|
| IVIG: intravenous immunoglobulin. *P value ≤ 0.5. | |||
| Gestational age | 37.9 ± 1.6 | 38.2 ± 1.6 | 0.18 |
| Birth weight | 3,022 ± 462 | 3,057 ± 511 | 0.16 |
| Male gender | 48 (51%) | 50 (46%) | 0.57 |
| Cesarean section | 47 (50) | 36 (33%) | 0.02* |
| Incompatibility | |||
| Rhesus | 21 (22%) | 11 (10%) | 0.02* |
| Major blood group (ABO) | 69 (73%) | 92 (85%) | 0.04 |
| Minor blood group | 4 (4%) | 2 (2%) | 0.31 |
| Outcome | IVIG group (n = 94) | Phototherapy group (n = 108) | P value |
|---|---|---|---|
| IVIG: intravenous immunoglobulin; TSB: total serum bilirubin; SD: standard deviation. *P value ≤ 0.05. | |||
| Duration of phototherapy (average ± SD), days | 3.5 ± 2.5 | 2.4 ± 1.8 | 1.1 |
| Length of hospital stay (average ± SD), days | 6.7 ± 4.1 | 6.9 ± 6.9 | 0.8 |
| Rebound hyperbilirubinemia | 47 (50%) | 31 (28.7%) | 0.002* |
| Need for exchange transfusion | 4 (4.2%) | 0 | 0.04* |
| Need for blood transfusion | 17 (18%) | 4 (3.7%) | 0.001* |
| Need for > 1 blood transfusion | 6 (6) | 0 | 0.03* |
| Readmission for blood transfusion | 3 (3.2%) | 3 (2.7%) | 0.86 |
| Readmission for phototherapy | 2 (2.1%) | 3 (2.7%) | 0.7 |
| Hemoglobin (average ± SD) | 11.8 ± 2.5 | 13.1 ± 2.5 | 0.0003* |
| Lowest hemoglobin value | 5.4 | 6.7 | |
| TSB mg/dL (average ± SD) | 14.6 ± 3.7 | 12.6 ± 3 | 0.0001* |
| Highest TSB value (mg/dL) | 36.3 | 20.8 | |
| Sepsis suspected | 4 (4.2%) | 29 (27%) | 0.00001* |
| Positive blood culture | 3 (3.2%) | 6 (5.6%) | 0.5 |