| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 11, Number 7, July 2019, pages 509-514
Connective Tissue Disorders in Patients With Thrombotic Thrombocytopenic Purpura: A Retrospective Analysis Using a National Database
Tables
| Patient characteristics | Without CTD | With CTD | P-value |
|---|---|---|---|
| CTD: connective tissue disorders; CI: confidence interval. | |||
| Total number of patients | 13,153 (91.3%) | 1,247 (8.7%) | |
| Gender, n (%) | < 0.01 | ||
| Male | 4,731 (36%) | 158 (12.7%) | |
| Female | 8,422 (64%) | 1,089 (87.3%) | |
| Race, n (%) | < 0.01 | ||
| White | 5,787 (47.3%) | 394 (34.4%) | |
| Black | 4,771 (39%) | 560 (48.9%) | |
| Hispanic | 990 (8%) | 123 (10.7%) | |
| Asian | 306 (2.5%) | 20 (1.8%) | |
| Native American | 75 (0.2%) | 9 (0.8%) | |
| Other | 311 (2.5%) | 39 (3.4%) | |
| Mean age, years (95% CI) | 48.64 (47.98 - 49.29) | 43.87 (41.96 - 45.79) | < 0.01 |
| Charlson comorbidity index score, n (%) | < 0.01 | ||
| 0 | 6,994 (53.2%) | 346 (27.7%) | |
| 1 | 2,073 (15.8%) | 329 (26.4%) | |
| 2 | 1,425 (10.8%) | 115 (9.3%) | |
| 3 | 2,661 (20.2%) | 457 (36.6%) | |
| Insurance type, n (%) | < 0.01 | ||
| Medicaid | 3,711 (29.7%) | 236 (20%) | |
| Medicare | 2,960 (23.7%) | 275 (23.2%) | |
| Private | 4,911 (39.2%) | 637 (53.9%) | |
| Uninsured | 929 (7.4%) | 34 (2.9%) | |
| Hospital bed size, n (%) | 0.7024 | ||
| Small | 1,082 (8.3%) | 114 (9.3%) | |
| Medium | 2,643 (20.2%) | 265 (21.6%) | |
| Large | 9,361 (71.5%) | 849 (69.1%) | |
| Receiving care in academic center, n (%) | 10,468 (80%) | 1,012 (82.4%) | 0.3535 |
| Receiving care in urban hospital, n (%) | 10,860 (99.5%) | 1,061 (100%) | 0.322 |
| Time to plasmapheresis, mean days (95% CI) | 2.77 (2.58 - 2.96) | 2.92 (2.48 - 3.36) | 0.5499 |
| Length of stay, mean days (95% CI) | 15.3 (14.7 - 15.8) | 18.2 (16.4 - 20.0) | < 0.01 |
| Total in-patient stay charge, mean (95% CI) | $59,358 ($57,062 - $61,654) | $76,166 ($66,311 - $86,022) | < 0.01 |
| Adjusted odds ratio | 95% confidence interval | P-value | |
|---|---|---|---|
| Primary outcome | |||
| Mortality | 0.96 | 0.54 - 1.70 | 0.882 |
| Secondary outcomes | |||
| Acute coronary syndrome | 0.84 | 0.43 - 1.64 | 0.616 |
| Cardiac arrest | 1.69 | 0.76 - 3.75 | 0.201 |
| Acute stroke | 0.80 | 0.44 - 1.46 | 0.468 |
| Need for mechanical ventilation | 1.24 | 0.76 - 2.04 | 0.389 |
| Need for hemodialysis | 1.39 | 0.97 - 2.00 | 0.075 |