Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |

Journal website http://www.jocmr.org |

Original Article

Volume 11, Number 5, May 2019, pages 367-374

**Association of Age and Anemia With Adiponectin Serum Levels in Normal-Weight Japanese Women**

Figures

Tables

Young (n = 311) | Middle-aged (n = 148) | Elderly (n = 322) | P# | ||
---|---|---|---|---|---|

Mean ± SD or n, %. #P values by ANOVA or Chi-square test. a, b: Young versus middle-aged and elderly, respectively; c: Middle-aged versus elderly: significantly different at P < 0.05 or less by Bonferroni’s multiple comparison procedures. HDL: high-density lipoprotein; SD: standard deviation; ANOVA: analysis of variance. | |||||

Age (years) | 20.5 ± 1.2 | 49.8 ± 3.6 | 77.9 ± 6.2 | < 0.001 | a, b, c |

Body mass index (kg/m^{2}) | 20.4 ± 2.2 | 22.0 ± 2.8 | 22.4 ± 3.0 | < 0.001 | a, b |

Cholesterol (mg/dL) | 182 ± 28 | 224 ± 35 | 218 ± 32 | < 0.001 | a, b |

HDL cholesterol (mg/dL) | 75 ± 13 | 77 ± 16 | 65 ± 15 | < 0.001 | b, c |

Leptin (ng/mL) | 8.6 ± 3.9 | 7.6 ± 4.9 | 8.2 ± 5.4 | ns | |

Adiponectin (mg/L) | 11.5 ± 4.3 | 11.8 ± 4.9 | 15.3 ± 7.8 | < 0.001 | b, c |

Red blood cells (10^{4}/µL) | 443 ± 32 | 445 ± 32 | 420 ± 35 | < 0.001 | b, c |

Hemoglobin (g/dL) | 13.0 ± 1.0 | 13.1 ± 1.3 | 12.8 ± 1.1 | 0.044 | |

Hematocrit (%) | 40.9 ± 2.9 | 41.4 ± 3.6 | 40.8 ± 3.1 | ns | |

Anemia (n, %) | 46 (14.8%) | 18 (12.2%) | 69 (21.5%) | 0.021 | |

Hyperadiponectinemia (n, %) | 12 (3.9%) | 5 (3.4%) | 73 (22.7%) | < 0.001 |

X (n = 95) | Y (n = 176) | Z (n = 51) | P# | ||
---|---|---|---|---|---|

Mean ± SD or n, %. #P values by ANOVA or Chi-square test. a, b: Young versus middle-aged and elderly, respectively; c: Middle-aged versus elderly: significantly different at P < 0.05 or less by Bonferroni’s multiple comparison procedures. X: Between 65 and 74 years; Y: Between 75 and 84 years; Z: Between 85 and 96 years. eGFR: estimated glomerular filtration rate; HDL: high-density lipoprotein; SD: standard deviation; ANOVA: analysis of variance. | |||||

Age (years) | 70.4 ± 2.8 | 79.2 ± 2.7 | 87.4 ± 2.3 | < 0.001 | a, b, c |

Body mass index (kg/m^{2}) | 22.6 ± 3.3 | 22.6 ± 2.9 | 21.5 ± 2.6 | 0.060 | |

Cholesterol (mg/dL) | 224 ± 33 | 215 ± 32 | 215 ± 30 | 0.059 | |

HDL cholesterol (mg/dL) | 66 ± 15 | 65 ± 15 | 65 ± 15 | 0.888 | |

Leptin (ng/mL) | 8.7 ± 5.2 | 8.3 ± 5.6 | 6.6 ± 4.5 | 0.078 | |

Adiponectin (mg/L) | 13.9 ± 6.9 | 15.1 ± 7.7 | 18.7 ± 8.6 | 0.001 | b, c |

Red blood cells (10^{4}/µL) | 437 ± 31 | 416 ± 32 | 404 ± 37 | < 0.001 | a, b |

Hemoglobin (g/dL) | 13.4 ± 1.0 | 12.7 ± 1.0 | 12.2 ± 1.1 | < 0.001 | a, b, c |

Hematocrit (%) | 42.3 ± 2.6 | 40.6 ± 3.0 | 38.9 ± 3.3 | < 0.001 | a, b, c |

Creatinine (mg/dL) | 0.63 ± 0.09 | 0.73 ± 0.15 | 0.80 ± 0.23 | < 0.001 | a, b, c |

eGFR (mL/min/1.73 m^{2}) | 71 ± 11 | 60 ± 12 | 55 ± 13 | < 0.001 | a, b, c |

Anemia (n, %) | 9 (9.5%) | 40 (22.9%) | 20 (39.2%) | < 0.001 | |

Hyperadiponectinemia (n, %) | 18 (18.9%) | 40 (22.7% | 18 (35.3%) | 0.079 |

Young | Middle-aged | Elderly | ||||
---|---|---|---|---|---|---|

r | P | r | P | r | P | |

^{a}Ranges of age (years): young, 18 - 24 years; middle-aged, 39 - 60 years; elderly, 65 - 96 years. HDL: high-density lipoprotein. | ||||||

Age^{a} | -0.044 | 0.084 | 0.201 | < 0.001 | ||

Body mass index | -0.203 | < 0.001 | -0.252 | < 0.01 | -0.353 | < 0.001 |

Cholesterol | 0.090 | 0.100 | 0.037 | |||

HDL cholesterol | 0.286 | < 0.001 | 0.322 | < 0.001 | 0.429 | < 0.001 |

Leptin | -0.182 | < 0.01 | -0.185 | < 0.05 | -0.346 | < 0.001 |

Red blood cells | -0.052 | -0.032 | -0.351 | < 0.001 | ||

Hemoglobin | -0.023 | 0.044 | -0.318 | < 0.001 | ||

Hematocrit | 0.037 | 0.042 | -0.314 | < 0.001 |

Hyperadiponectinemia | P values | ||
---|---|---|---|

Yes (n = 76) | No (n = 246) | ||

Mean ± SD or n, %. HDL: high-density lipoprotein; SD: standard deviation. | |||

Age (years) | 79 ± 7 | 77 ± 6 | 0.014 |

Body mass index (kg/m^{2}) | 20.9 ± 2.8 | 22.9 ± 2.9 | < 0.001 |

Cholesterol (mg/dL) | 222 ± 30 | 217 ± 32 | 0.18 |

HDL cholesterol (mg/dL) | 75 ± 15 | 62 ± 13 | < 0.001 |

Leptin (ng/mL) | 5.2 ± 3.3 | 9.1 ± 5.6 | < 0.001 |

Adiponectin (mg/L) | 26.4 ± 6.3 | 11.9 ± 4.2 | < 0.001 |

Red blood cells (10^{4}/µL) | 403 ± 34 | 426 ± 33 | < 0.001 |

Hemoglobin (g/dL) | 12.3 ± 1.0 | 13.0 ± 1.1 | < 0.001 |

Hematocrit (%) | 39.5 ± 3.1 | 41.3 ± 3.0 | < 0.001 |

Anemia (n, %) | 24 (31.6%) | 45 (18.4%) | 0.014 |