Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 11, Number 6, June 2019, pages 422-427


Polycythemia in Patients With Hereditary Hemochromatosis: Real or Myth?

Figure

Figure 1.
Figure 1. HFE mutations in study participants (n = 160).

Tables

Table 1. Patient Characteristics (n = 152)
 
HFE mutationNumber of patients (n)MenWomenMedian age (years)Median hemoglobin (g/dL)Median hematocrit (%)Median ferritin (ng/mL)Phlebotomy (n/n)Active tobacco useLung diseaseSignificant medical conditions
OSA: obstructive sleep apnea; GI: gastrointestinal; COPD: chronic obstructive pulmonary disease; PE: pulmonary embolism; ESRD: end-stage renal disease.
C282Y/C282Y4429156415.544.9502.538/446/44OSA = 3Crohn’s = 1
C282Y/H63D27171057.515.846294.520/277/27OSA = 1Menorrhagia = 3, GI bleeding = 1
H63D/H63D105562.516474516/102/10NoneNone
H63D/S65C1103517.5491801/10/1NoneNone
C282Y heterozygous25131257164728315/254/25OSA = 2GI bleeding = 1
H63D heterozygous4128135916.64826019/4114/41OSA = 5, COPD = 1, PE = 1ESRD = 2, folate deficiency = 1
C2A2Y heterozygous1107015.8485681/10/1NoneNone
S65c heterozygous211691647.95412/20/2NoneNone
Total cohort152965660.516.147306102/15233/15213/1529/152

 

Table 2. Comparison of Hemoglobin and Hematocrit Levels Between Men and Women
 
HFE mutationGenderHemoglobin range (g/dL)Hematocrit range (%)Median hemoglobin (g/dL)Median hematocrit (%)
C282Y/C282YMale, female13 - 19.5, 14 - 16.238 - 57, 40 - 4616.4, 14.446, 42
C282Y/H63DMale, female13.4 - 18.4, 12.8 - 16.940 - 55, 37 - 5016.4, 1547, 44.6
H63D/H63DMale, female15.5 - 19, 14.1 - 17.745 - 55, 42 - 5316.5, 1550.1, 45
H63D/S65CMale17.549--
C282Y heterozygousMale, female14.4 - 18.3, 13.3 - 16.441 - 55, 39.2 - 5616.3, 15.147, 44
H63D heterozygousMale, female13.5 - 19.6, 14 - 19.839 - 57, 41 - 56.317.1, 15.949, 46
C2A2Y heterozygousMale15.848--
S65c heterozygousMale, female15.4, 16.644.4, 57.3--

 

Table 3. Median Ferritin Levels in Patients Receiving and not Receiving Phlebotomy in Each Subset of HFE Mutations
 
HFE mutationNumber of patients (n)PhlebotomyMedian ferritin (ng/mL)No phlebotomyMedian ferritin (ng/mL)
C282Y/C282Y44385356167
C282Y/H63D2720435.57218
H63D/H63D1067024136.5
C282Y heterozygous251546510121
H63D heterozygous411941222143.5