J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 11, Number 8, August 2019, pages 543-549

Possible Impact of Spinal Anesthesia and Phenylephrine on Sublingual Microcirculation of Cesarean Delivery Patients

Figures

Figure 1. Mean MFI measurements pre- and post-spinal anesthesia entire cohort. Thick, solid line in the box represents the mean, whiskers represent the 95% confidence interval and solid dots are participants. MFI: microvascular flow index.

Figure 2. MFI measurements pre- and post-spinal anesthesia for the (a) phenylephrine infusion and (b) phenylephrine bolus groups.

Figure 3. Post-spinal MFI between infusion and bolus groups was not significantly different (P = 0.22). Thick, solid line in the box represents the mean, whiskers represent the 95% confidence interval and solid dots are participants. MFI: microvascular flow index.

Tables

**Table 1.** Demographic Characteristics
	Phenylephrine infusion (n = 11)	Phenylephrine bolus (n = 11)	P-value
Data presented as mean ± SD or median (IQR). BMI: body mass index; SD: standard deviation; IQR: interquartile range; SBP: systolic blood pressure.
Age (years)	32 ± 5	34 ± 5	0.31
BMI (kg/m²)	29 ± 3	29 ± 3	0.88
Gestational age (weeks)	39 ± 1	39 ± 1	0.57
Gravidity	2 (2 - 3)	2 (1 - 3)	0.71
Parity	1 (1 - 1)	1 (0 - 1)	0.42
Baseline SBP (mm Hg)	113 ± 6	117 ± 10	0.09

**Table 2.** Intraoperative Characteristics
	Phenylephrine infusion (n = 11)	Phenylephrine bolus (n = 11)	P-value
Data presented as mean ± SD. SD: standard deviation.
Duration of surgery (min)	53 ± 27	43 ± 9	0.15
Total fluids given (mL)	1,559 ± 412	1,891 ± 419	0.08
Estimated blood loss (mL)	586 ± 158	500 ± 140	0.19

**Table 3.** Additional Post-Spinal Microcirculation Measures
	Phenylephrine infusion (n = 11)	Phenylephrine bolus (n = 11)	Mean difference (95% CI)	P-value
CI: confidence interval.
Total vessel density	22.9 ± 4.1	23.3 ± 4.0	-0.4 (-4.4 to 3.6)	0.80
Perfused vessel density	21.2 ± 4.1	19.7 ± 4.3	1.5 (-2.2 to 5.3)	0.40
Proportion of perfused vessels	92.9 ± 6.8	85.3 ± 15.6	7.6 (-3.1 to 18.3)	0.15