J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 11, Number 2, February 2019, pages 127-132

Effect of Troponin I Elevation on Duration of Mechanical Ventilation and Length of Intensive Care Unit Stay in Patients With Sepsis

Figure 1. Flow chart of patients who were admitted to ICU with possible sepsis and underwent intubation and mechanical ventilation.

**Table 1.** Characteristics of Patients Who Were Admitted to ICU With Possible Sepsis and Underwent Intubation and Mechanical Ventilation
	Troponin positive (N = 45)	Troponin negative (N = 80)	P value
Demographics
Age	74.4	70.3
Male (%)	29 (64.4%)	50 (62.5%)	0.82
Vital signs
Systolic blood pressure	117.4	113.6	0.55
Diastolic blood pressure	64.8	63.7	0.57
Heart rate	98	93	0.48
Respiratory rate	22	21	0.31
Temperature F	98.8	97.9	0.18
Confusion (%)	30 (66.7%)	57 (71.3%)	0.59
Labs
WBCs (mean ± SD)	16.8 ± 8.5	12.9 ± 6.3	0.015
Lactate (mean ± SD)	3.3 ± 3	2.1 ± 1.7	0.013
Chronic conditions
Heart failure (%)	10 (22.2%)	23 (28.7%)	0.42
Diabetes mellitus (%)	18 (40%)	39 (48.8%)	0.34
Coronary artery disease (%)	12 (26.7%)	24 (30%)	0.69
Chronic kidney disease (%)	9 (20%)	14 (17.5%)	0.72
Chronic obstructive pulmonary disease (%)	11 (24.4%)	24 (30%)	0.5

Table 1. Characteristics of Patients Who Were Admitted to ICU With Possible Sepsis and Underwent Intubation and Mechanical Ventilation

Troponin positive (N = 45)

Troponin negative (N = 80)

P value

Demographics

Age

74.4

70.3

Male (%)

29 (64.4%)

50 (62.5%)

0.82

Vital signs

Systolic blood pressure

117.4

113.6

0.55

Diastolic blood pressure

64.8

63.7

0.57

Heart rate

0.48

Respiratory rate

0.31

Temperature F

98.8

97.9

0.18

Confusion (%)

30 (66.7%)

57 (71.3%)

0.59

Labs

WBCs (mean ± SD)

16.8 ± 8.5

12.9 ± 6.3

0.015

Lactate (mean ± SD)

3.3 ± 3

2.1 ± 1.7

0.013

Chronic conditions

Heart failure (%)

10 (22.2%)

23 (28.7%)

0.42

Diabetes mellitus (%)

18 (40%)

39 (48.8%)

0.34

Coronary artery disease (%)

12 (26.7%)

24 (30%)

0.69

Chronic kidney disease (%)

9 (20%)

14 (17.5%)

0.72

Chronic obstructive pulmonary disease (%)

11 (24.4%)

24 (30%)

0.5

**Table 2.** Sources of Infection in Patients Who Were Admitted to ICU With Possible Sepsis and Underwent Intubation and Mechanical Ventilation
	Troponin negative (N = 80)	Troponin positive (N = 45)
Respiratory	62 (77.5%)	38 (84.4%)	100 (80%)
Urinary tract	12 (15%)	4 (8.9%)	16 (12.8%)
Intraabdominal	5 (6.3%)	2 (4.4%)	7 (5.6%)
Cutaneous	1 (1.3%)	0 (0%)	1 (0.8%)
Others	0 (0%)	1 (2.2%)	1 (0.8%)

Table 2. Sources of Infection in Patients Who Were Admitted to ICU With Possible Sepsis and Underwent Intubation and Mechanical Ventilation

Troponin negative (N = 80)

Troponin positive (N = 45)

Respiratory

62 (77.5%)

38 (84.4%)

100 (80%)

Urinary tract

12 (15%)

4 (8.9%)

16 (12.8%)

Intraabdominal

5 (6.3%)

2 (4.4%)

7 (5.6%)

Cutaneous

1 (1.3%)

0 (0%)

1 (0.8%)

Others

0 (0%)

1 (2.2%)

1 (0.8%)

**Table 3.** Septic Shock and In-Hospital Mortality in Intubated ICU Patients Admitted With Sepsis
	Troponin positive (N = 45)	Troponin negative (N = 80)	RR (95% CI)	P value
Septic shock (%)	28 (62.2%)	35 (43.8%)	1.42 (1.015 - 1.99)	0.04
In-hospital mortality (%)	11 (24.4%)	12 (15%)	1.6 (0.78 - 3.4)	0.19

Table 3. Septic Shock and In-Hospital Mortality in Intubated ICU Patients Admitted With Sepsis

Troponin positive (N = 45)

Troponin negative (N = 80)

RR (95% CI)

P value

Septic shock (%)

28 (62.2%)

35 (43.8%)

1.42 (1.015 - 1.99)

0.04

In-hospital mortality (%)

11 (24.4%)

12 (15%)

1.6 (0.78 - 3.4)

0.19

**Table 4.** Duration of Mechanical Ventilation (hours), ICU Length of Stay (days) and Hospital Length of Stay (days) in Intubated ICU Patients Admitted With Sepsis
	Troponin positive (N = 45)	Troponin negative (N = 80)	95% CI	P value
Duration of mechanical ventilation in hours (mean ± SD)	55.6 ± 24.8	49.6 ± 33	0.001 - 0.063	0.032
ICU length of stay in days (mean ± SD)	4.6 ± 3.1	4.3 ± 3	0.13 - 0.27	0.2
Hospital length of stay in days (mean ± SD)	9.7 ± 6	8.4 ± 4.4	0.187 - 0.341	0.264

Table 4. Duration of Mechanical Ventilation (hours), ICU Length of Stay (days) and Hospital Length of Stay (days) in Intubated ICU Patients Admitted With Sepsis

Troponin positive (N = 45)

Troponin negative (N = 80)

95% CI

P value

Duration of mechanical ventilation in hours (mean ± SD)

55.6 ± 24.8

49.6 ± 33

0.001 - 0.063

0.032

ICU length of stay in days (mean ± SD)

4.6 ± 3.1

4.3 ± 3

0.13 - 0.27

0.2

Hospital length of stay in days (mean ± SD)

9.7 ± 6

8.4 ± 4.4

0.187 - 0.341

0.264