J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 11, Number 1, January 2019, pages 15-20

Effects of Sitagliptin on Pancreatic Beta-Cells in Type 2 Diabetes With Sulfonylurea Treatment: A Prospective Randomized Study

Figures

Figure 1. Study protocol.

Figure 2. (a) Changes in HbA1c level over the 24-week treatment period. Actual mean values of HbA1c in the two groups at 0, 12 and 24 weeks are shown. The values are expressed as means ± SEM. A statistical analysis was performed by paired t-test. *P < 0.01 versus 0 week. (b) The amount of change in HbA1c from 0 to 24 weeks of the examination.

Figure 3. Changes in fasting plasma glucose level (a), fasting insulin concentration (b), proinsulin/insulin ratio (c) and urinary albumin (d) over the 24-week treatment period. The fasting plasma glucose level was decreased significantly in the S group (a). No significant changes in fasting insulin concentration were observed in either group, although a decreasing tendency was observed in the G group and an increasing tendency was seen in the S group (b). P/I ratio in the G group was significantly increased, while that in the S group was decreased although the difference did not reach statistical significance (c). The urinary albumin excretion tended to increase in the G group, although the difference was not statistically significant (d).

Table

**Table 1.** Clinical Characteristics
	G group (n = 19)	S group (n = 22)	P value
G group: glimepiride group; S group: sitagliptin group.
Age (years)	62.1 ± 9.0	63.4 ± 5.9	0.940
Disease duration (years)	11.9 ± 4.9	12.9 ± 6.8	0.699
Body mass index (kg/m²)	24.6 ± 3.5	24.0 ± 2.4	0.432
Systolic blood pressure (mm Hg)	137 ± 17	130 ± 9	0.481
Diastolic blood pressure (mm Hg)	80 ± 8	78 ± 9	0.207
Fasting blood glucose (mg/dL)	176 ± 43	175 ± 34	0.504
Immunoreactive insulin (IU/mL)	8.9 ± 5.7	7.2 ± 4.0	0.687
HbA1c (%)	7.8 ± 0.5	8.0 ± 0.6	0.423
Urinary albumin (mg/g Cr)	43.7 ± 76.2	33.8 ± 45.2	0.852
Total cholesterol (mg/dL)	209 ± 40	202 ± 35	0.447
HDL-cholesterol (mg/dL)	56 ± 14	59 ± 19	0.339
Triglyceride (mg/dL)	220 ± 226	136 ± 49	0.085
Non-HDL-cholesterol (mg/dL)	153 ± 49	143 ± 34	0.394