Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 10, Number 7, July 2018, pages 601-605


Secondary Salivary Gland Malignancy in Thyroid Cancer: A United States Population Based Study

Tables

Table 1. Secondary Salivary Gland Malignancy in Patients With Thyroid Cancer
 
Secondary salivary malignancy
ObservedO/E95% CI of O/EExcess risk
CI: confidence interval; O/E: observed to expected ratio; RAI: radioactive iodine.
Total Cases183.582.12 - 5.650.48
Age
  < 60 years124.512.33 - 7.880.44
  ≥ 60 years62.530.93 - 5.500.64
Gender
  Male21.130.14 - 4.070.04
  Female164.912.80 - 7.970.59
Race
  White133.041.62 - 5.190.39
  Black25.200.63 - 18.790.70
  Asian or Pacific Islander39.381.93 - 27.411.18
Grade of thyroid malignancy
  I - well differentiated79.703.90 - 19.981.56
  II - moderately differentiated00.000.00 - 19.54-0.20
  III - poorly differentiated114.520.37 - 80.883.56
  IV - undifferentiated00.000.00 - 636.06-0.24
  Unknown102.471.18 - 4.540.27
Radioactive iodine therapy
  No RAI62.180.80 - 4.740.23
  RAI125.262.72 - 9.190.76
Latency period
  2 - 5 months13.940.10 - 21.970.49
  6 - 11 months38.251.70 - 24.101.21
  12 - 59 months93.821.75 - 7.250.50
  60 - 119 months53.111.01 - 7.250.42
  120+ months00.000.00 - 8.18-0.22

 

Table 2. Characteristics of Primary and Secondary Salivary Gland Malignancy
 
Primary Salivary MalignancySecondary Salivary Malignancy
n%n%
Total cases19,008-18-
Age at diagnosis59.80 ± 18.361)53.28 ± 16.634)P = 0.132
Age groupP = 0.07
  < 60 years8,61545.3%1266.7%
  ≥ 60 years10,39354.7%633.3%
GenderP < 0.05
  Male10,24053.9%211.1%
  Female8,76846.1%1688.9%
RaceP = 0.51
  White15,63082.2%1372.2%
  Black1,6568.7%211.1%
  Other1,4867.8%316.7%
  Unknown2361.2%00%
Primary siteP = 0.48
  C07.9 - parotid gland15,13479.6%1794.4%
  C08.0 - submandibular gland2,84515%00%
  C08.1 - sublingual gland1841.0%00%
  C08.8 - overlapping lesion of major salivary glands200.1%00%
  C08.9 - major salivary gland, NOS8254.3%15.6%
Grade of salivary cancerP = 0.08
  I - well differentiated1,7339.1%422.2%
  II - moderately differentiated3,33717.5%527.8%
  III - poorly differentiated3,32217.5%15.6%
  IV - undifferentiated1,4877.9%00%
  Unknown9,12948%844.4%