Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 10, Number 5, May 2018, pages 419-428

The Role of Urinary Neutrophil Gelatinase-Associated Lipocalin in Predicting Acute Kidney Dysfunction in Patients With Liver Cirrhosis

Figures

Figure 1.
Figure 1. Correlation between uNGAL and serum creatinine level at daily intervals in all participants (a, b, c, d, e, f).
Figure 2.
Figure 2. Area under the curve for highest uNGAL in 6 days considering abnormal creatinine as a positive state variable.
Figure 3.
Figure 3. Area under the curve for highest uNGAL in 6 days considering abnormal eGFR as a positive state variable.
Figure 4.
Figure 4. Correlation between high uNGAL level at the first 6 days of admission and low eGFR at 6 weeks of follow-up (a, b, c, d, e, f).

Tables

Table 1. Demographics and Clinical Features of the Study Cohort
 
VariablesMean ± SD/number (%)
SD: standard deviation; NGAL: neutrophil gelatinase-associated lipocalin; BUN: blood urea nitrogen; NASH: non-alcoholic steatohepatitis; CTP: Child-Turcotte-Pugh score; MELD: model for end-stage liver disease score.
Total sampleN = 57
Age55.9 ± 11.0
Gender
  Male33 (57.9%)
  Female24 (42.1%)
Serum creatinine (µmol/L) (6 days)88.5 ± 37.1
uNGAL (ng/mL) (6 days)69.0 ± 63.7
Serum BUN (mmol/L) (2 days)7.6 ± 5.3
Etiology
  Hepatitis B12 (21.1%)
  Hepatitis C26 (45.6%)
  Autoimmune hepatitis5 (8.8%)
  NASH-related10 (17.5%)
  Cryptogenic1 (1.8%)
  Alcohol3 (5.3%)
CTP
  Class A3 (5.3%)
  Class B24 (42.1%)
  Class C30 (52.6%)
MELD
  Low score (good prognosis)23 (40.4%)
  Medium score (moderate prognosis)16 (28.1%)
  High score (poor prognosis)18 (31.6%)

 

Table 2. Correlation Between uNGAL and Serum Creatinine Level at Daily Intervals in All Participants
 
Serum creatinine levelrP-value
uNGAL: urinary neutrophil gelatinase-associated lipocalin; r: correlation coefficient.
uNGALDay 1-0.030.82
uNGALDay 20.170.22
uNGALDay 30.030.02
uNGALDay 40.490.00
uNGALDay 50.480.001
uNGALDay 60.130.49