Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 10, Number 3, March 2018, pages 260-267


The Role of C-Peptide as Marker of Cardiometabolic Risk in Women With Polycystic Ovary Syndrome: A Controlled Study

Tables

Table 1. Clinical, Metabolic and Hormonal Baseline Characteristics of Normal Cycling Women and Polycystic Ovary Syndrome Patients
 
VariablesControlPCOSP*
MeanSEMMeanSEM
PCOS: polycystic ovary syndrome. *Pearson’s correlation coefficient.
Clinical
  SBP (mm Hg)114.070.59117.900.61< 0.001
  DBP (mm Hg)73.250.5575.560.540.002
Anthropometrical
  Body weight (kg)63.570.7574.760.87< 0.001
  BMI (kg/m2)24.510.3029.000.33< 0.001
  WC (cm)73.510.5985.790.75< 0.001
  W/H ratio0.740.000.790.00< 0.001
  CI1.070.001.150.00< 0.001
  FM (kg)19.850.5128.690.62< 0.001
  LBM (kg)43.490.3436.680.41< 0.001
  VAI0.760.032.430.11< 0.001
Metabolic
  Glucose (nmol/L)4.670.035.000.03< 0.001
  Insulin (µmol/L)50.912.3497.923.36< 0.001
  HbA1C (%)4.990.035.800.15< 0.001
  C-peptide (nmol/L)0.540.010.770.02< 0.001
  C-pep/glucose ratio0.110.000.0150.00< 0.001
  Insulin/C-pep ratio104.884.83130.873.45< 0.001
  C-pep/insulin ratio0.020.010.0020.001<0.001
  LAP15.730.9947.022.62< 0.001
  HOMA-IR0.980.041.820.06< 0.001
  HOMA %B103.393.17137.962.95< 0.001
  HOMA S138.135.8680.542.86< 0.001
  TC (mmol/L)4.330.544.690.500.624
  TG (mmol/L)0.930.021.600.13< 0.001
  HDL (< 0.001 mmol/L)1.460.061.180.01< 0.001
  LDL-c (mmol/L)2.580.092.910.070.004
  VLDL-c (mmol/L)0.450.010.620.02< 0.001
Hormonal
  Testo T (nmol/L)1.050.031.950.04< 0.001
  Free T (pmol/L)0.010.000.040.00< 0.001
  FAI (%)2.170.126.930.27< 0.001
  FEI (%, pg/nmol)0.530.010.660.02< 0.001
  E2 (pmol/L)177.926.60242.7510.15< 0.001
  17-OHP4 (nmol/L)2.590.083.650.11< 0.001
  PRL (pmol/L)695.9125.56571.6615.51< 0.001

 

Table 2. Simple Correlation Between C-Peptide and Selected Clinical, Anthropometrical, Hormonal and Metabolic Cardiovascular Risk Markers in Polycystic Ovary Syndrome and Normal Cycling Women
 
VariablesPCOSControl
rP*rP*
PCOS: polycystic ovary syndrome. *Pearson’s correlation coefficient.
Clinical
  SBP (mm Hg)0.3140.0000.0160.808
  DBP (mm Hg)0.2650.0000.0720.285
Anthropometrical
  Body weight (kg)0.5090.0000.3560.000
  BMI (kg/m2)0.5810.0000.3320.000
  WC (cm)0.5650.0000.4280.000
  W/H ratio0.4590.0000.2580.000
  CI0.3530.0000.2400.000
  FM (kg)0.5490.0000.3760.000
  LBM (kg)0.3110.0000.2670.000
  VAI0.5390.0000.3170.000
Metabolic
  Glucose (nmol/L)0.3810.0000.2940.000
  Insulin (µmol/L)0.6020.0000.6210.000
  HbA1C (%)0.3510.0000.1870.007
  C-peptide (nmol/L)----
  C-pep/glucose ratio0.9670.0000.9740.000
  Insulin/C-pep ratio-0.1640.002-0.2310.002
  C-pep/insulin ratio0.1670.0010.2340.002
  LAP0.4340.0000.4330.000
  HOMA-IR0.5920.0000.6300.000
  HOMA %B0.4450.0000.3870.000
  HOMA S-0.5430.000-0.5170.000
  TC (mmol/L)0.2180.0000.0410.537
  TG (mmol/L)0.4520.0000.2710.000
  HDL (mmol/L)-0.3490.000-0.0970.144
  LDL-c (mmol/L)0.1190.027-0.0070.920
  VLDL-c (mmol/L)0.4180.0000.4040.000
Hormonal
  Testo T (nmol/L)0.1820.0000.0180.782
  Free F (pmol/L)0.3220.0000.1460.027
  FAI (%)0.4570.0000.2500.000
  E2 (pmol/L)0.1460.0090.0760.275
  FEI (%, pg/nmol)0.5170.000.4210.000
  17-OHP4 (nmol/L)-0.0360.486-0.0790.238
  PRL (pmol/L)-0.1910.0000.1150.087

 

Table 3. Stepwise Multiple Correlation Between C-Peptide and Known Predictors of Dysmetabolic Disease in Normal Cycling Women
 
ModelRR2Adjusted R2Standard error of estimateChange statisticsSig. F changeDurbin- Watson
R2 changeF change
aPredictor: (constant), fasting C-peptide/glucose ratio. bPredictor: (constant), fasting C-peptide/glucose ratio, glucose. cPredictor: (constant), fasting C-peptide/glucose ratio, glucose, VAI.
10.962a0.9260.9250.0580210.935962.0280.000
20.996b0.9930.9930.0179850.0685,368.9950.000
30.997c0.9940.9930.1733840.0003,833.1050.0001.979

 

Table 4. Stepwise Multiple Regression Between C-Peptide and Known Predictors of Dysmetabolic Disease in Patients With Polycystic Ovary Syndrome
 
ModelRR2Adjusted R2Standard error of estimateChange statisticsSig. F changeDurbin- Watson
R2 changeF change
aPredictor: (constant), fasting C-peptide/glucose ratio. bPredictor: (constant), fasting C-peptide/glucose ratio, glucose. cPredictor: (constant), fasting C-peptide/glucose ratio, glucose, body weight. dPredictor: (constant), fasting C-peptide/glucose ratio, glucose, body weight, FEI.
10.974a0.9500.94996.095690.9502,884.2990.000
20.994b0.9870.98748.643690.038445.0990.000
30.994c0.9880.98847.509300.0018.3450.004
40.994d0.9880.98846.568800.0017.1610.0082.031