| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 9, Number 8, August 2017, pages 701-708
Autologous Stromal Vascular Fraction in the Intravenous Treatment of End-Stage Chronic Obstructive Pulmonary Disease: A Phase I Trial of Safety and Tolerability
Tables
| Age | Sex | Method of search | Local physician input on study participation | Smoking (PYH) | Infusion side effects | Pre ASC oxygen | Hospitalizations pre ASC |
|---|---|---|---|---|---|---|---|
| PYH: per year history; ASCs: adipose stem cells; ER: emergency room. | |||||||
| 72 | M | Internet | Pulmonologist: indifferent | 40 | None | 3 | 1 hospital, ER 6 - 8 wks prior |
| M | Internet | Pulmonologist: supportive | 100 | None | 3 | 1 | |
| F | Internet | Physicians indifferent | 75 | None | 2 | Monthly | |
| F | Internet | Internist: supportive; pulmonologist: recommended against | 70 | None | 2 | Bi-yearly | |
| 70 | M | Internet | Pulmonologist: indifferent | 50 | Liposuction painful, IV infiltration: new IV started | 0 | 1 ER |
| 61 | F | Internet | Internist: supportive; pulmonologist/cardiologist against | 40 | None | 2 | No |
| 73 | F | Internet | Pulmonologist: recommended against | 45 | None | 2 | No |
| F | Internet | Physician indifferent | 50 | None | 2 | 1 ER | |
| 69 | M | Internet | Did not consult with physician | 60 | None | 2 | 1 ER |
| 57 | F | Internet | Kaiser physician was “insulted” that patient would consider non-approved therapy | 20 | None | 2 | Yes |
| 63 | M | Internet | Pulmonologist: doubtful of approach but did not advise against participation | 90 | Liposuction painful | 3 | Yes |
| M | Another study participant | Internist: against approach | Little but welder so environmental exposure | None | 2.5 | No | |
| Age | Sex | Smoking (PY) | Time post-infusion at independent interview (months) | Time to optimal subjective effect | Time course of overall effect | Waning of effect over time | Do it again? | Other comments and effects noted (undirected) |
|---|---|---|---|---|---|---|---|---|
| PY: packs per year; UTI: urinary track infection; RLL: right lower lobe; SOB: shortness of breath. | ||||||||
| 72 | M | 40 | 13 | 1 day | Continually getting better | No | Yes | Lethargy, memory loss, pallor gone, arthritis gone for 2 months, actinic keratosis better, increased sex drive, better hearing, exercises |
| M | 100 | 17 | 1 month | Continually getting better | No | Yes | Sounds and looks better | |
| F | 75 | 1 month | Continually getting better | No | Yes | Off prednisone | ||
| F | 70 | 1 month | 3 months | Yes | No (yes if cost-free) | Looks better, no cough, no bronchitis | ||
| 70 | M | 50 | 23 | None | None | Yes | No (yes if cost-free) | Getting worse |
| 61 | F | 40 | 15 | 1 month | Continually getting better | No | No (yes if cost-free) | Feels stronger and does not get URIs, but not oxygen-independent which is what was hoped for |
| 73 | F | 45 | 12 | None | None | Yes | Yes | Thyroid is better; pulmonologist decreasing thyroid meds |
| F | 50 | 27 | 1 day | 3 months | Yes | Yes | 15-20% increase in breathing capabilities initially, now baseline; RLL malignancy discovered after treatment; cough better since treatment | |
| 69 | M | 60 | 20 | 1 month | Gradually getting worse after first month | Yes | No (yes if cost-free) | Easier oxygen intake, but no difference |
| 57 | F | 20 (quit 2009) | instantly | 1 month | No | Yes | Also had similar infusions (3) at another (US) facility. Noted that fatigue lessened and post-exertional recovery improved. | |
| 63 | M | 90 | 7 | None | None | None | No | On UCLA lung transplant program |
| M | Little but welder so environmental exposure | 18 | 1 day | Continually getting better | No | Yes, if he could receive without travel | Fewer panic attacks due to SOB, wife noticed patient has been less confused and has had fewer other medical issues; still on oxygen | |