Figure 1. Study protocol. ARB: angiotensin II receptor blocker; BP: blood pressure; BPV: blood pressure variability.
| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 9, Number 7, July 2017, pages 618-623
Effect of Azilsartan on Day-to-Day Variability in Home Blood Pressure: A Prospective Multicenter Clinical Trial
Figure
Tables
| Data are expressed as mean ± standard deviation or number (%). | |
| Age, years | 69 ± 11 |
| Men, n (%) | 13 (46%) |
| Body mass index (kg/m2) | 24.2 ± 3.6 |
| Diabetes mellitus, n (%) | 3 (17%) |
| Dyslipidemia, n (%) | 12 (43%) |
| Chronic kidney disease, n (%) | 5 (18%) |
| History of coronary artery disease, n (%) | 2 (7%) |
| History of cerebrovascular disease, n (%) | 2 (7%) |
| Current smoker, n (%) | 1 (4%) |
| Angiotensin receptor blockers before enrollment | |
| Candesartan 4 mg, n (%) | 19 (67%) |
| Losartan 50 mg, n (%) | 1 (4%) |
| Olmesartan 20 mg, n (%) | 6 (21%) |
| Valsartan 80 mg, n (%) | 1 (4%) |
| Telmisartan 40 mg, n (%) | 1 (4%) |
| Concomitant medications | |
| Calcium channel blockers, n (%) | 11 (39%) |
| Diuretics, n (%) | 2 (7%) |
| Beta blockers, n (%) | 5 (18%) |
| Baseline | 12 weeks | 24 weeks | |
|---|---|---|---|
| Data are expressed as mean ± standard deviation. BP: blood pressure. | |||
| Office | |||
| Systolic BP (mm Hg) | 140.3 ± 15.7 | 139.3 ± 19.4 | 136.8 ± 16.0 |
| Diastolic BP (mm Hg) | 80.3 ± 13.7 | 79.8 ± 12.3 | 76.8 ± 11.2 |
| Heart rate (beats/min) | 77.3 ± 12.6 | 76.1 ± 12.2 | 74.6 ± 10.7 |
| Home (morning) | |||
| Systolic BP (mm Hg) | 136.9 ± 13.1 | 136.2 ± 12.0 | 133.3 ± 10.0 |
| Diastolic BP (mm Hg) | 79.9 ± 10.2 | 79.2 ± 9.9 | 79.6 ± 9.6 |
| HR (beats/min) | 67.4 ± 7.6 | 68.2 ± 8.6 | 67.1 ± 7.1 |
| Home (evening) | |||
| Systolic BP (mm Hg) | 134.2 ± 16.6 | 130.1 ± 14.3 | 130.2 ± 10.8 |
| Diastolic BP (mm Hg) | 76.3 ± 11.8 | 75.4 ± 10.3 | 73.2 ± 9.0 |
| Heat rate (beats/min) | 67.5 ± 6.2 | 69.5 ± 6.2 | 64.2 ± 6.7 |
| Baseline | 12 weeks | 24 weeks | |
|---|---|---|---|
| Data are expressed as mean ± SD. BP: blood pressure; SD: standard deviation; CV: coefficient of variation. *P < 0.05 vs. baseline. | |||
| Morning | |||
| Systolic BP | |||
| SD (mm Hg) | 7.4 ± 3.6 | 6.3 ± 3.3* | 6.1 ± 3.2* |
| CV (%) | 5.4 ± 2.7 | 4.6 ± 2.4* | 4.6 ± 2.3* |
| Diastolic BP | |||
| SD (mm Hg) | 4.8 ± 2.8 | 3.9 ± 1.7* | 3.6 ± 1.9* |
| CV (%) | 5.9 ± 3.5 | 4.8 ± 2.3* | 4.5 ± 2.4 |
| Evening | |||
| Systolic BP | |||
| SD (mm Hg) | 6.9 ± 3.7 | 6.2 ± 3.1 | 6.2 ± 3.2 |
| CV (%) | 5.1 ± 2.5 | 4.8 ± 2.2 | 4.8 ± 2.4 |
| Diastolic BP | |||
| SD (mm Hg) | 4.2 ± 2.4 | 4.0 ± 2.0 | 4.1 ± 2.2 |
| CV (%) | 5.5 ± 2.6 | 5.3 ± 2.6 | 5.6 ± 3.0 |