Figure 1. Time courses of systolic and diastolic blood pressure (SBP and DBP) and pulse rate (PR) in the control and changeover groups. *P < 0.05 vs. 0 weeks.
| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 8, Number 12, December 2016, pages 888-892
Efficacy and Safety of a Single-Pill Fixed-Dose Combination of Azilsartan and Amlodipine
Figure
Tables
| All patients (n = 39) | Control group (n = 20) | Changeover group (n = 19) | |
|---|---|---|---|
| BMI: body mass index; DM: diabetes mellitus; DL: dyslipidemia; HU: hyperuricemia; CKD: chronic kidney disease; CCB: calcium channel blocker. | |||
| Age (years) | 73 ± 12 | 75 ± 12 | 71 ± 12 |
| Male (%) | 44 | 35 | 53 |
| BMI (kg/m2) | 25 ± 4 | 25 ± 4 | 25 ± 4 |
| Smoking (%) | 44 | 40 | 47 |
| DM (%) | 33 | 35 | 32 |
| DL (%) | 77 | 80 | 74 |
| HU (%) | 28 | 25 | 32 |
| CKD (%) | 33 | 40 | 26 |
| Medications | |||
| β-blocker (%) | 15 | 25 | 5 |
| α-blocker (%) | 5 | 0 | 11 |
| Diuretic (%) | 28 | 35 | 21 |
| Control group(n = 20) | Changeover group (n = 19) | |||||
|---|---|---|---|---|---|---|
| 0W | 8W | 16W | 0W | 8W | 16W | |
| UN: urea nitrogen; Cr: creatinine; UA: uric acid; Na: sodium; K: potassium; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglyceride; FPG: fast plasma glucose; HbA1c: hemoglobin A1c; BNP: brain natriuretic peptide. | ||||||
| UN, mg/dL | 18 ± 6 | 17 ± 5 | 17 ± 6 | 16 ± 7 | 17 ± 5 | 16 ± 5 |
| Cr, mg/dL | 0.9 ± 0.3 | 0.9 ± 0.3 | 0.9 ± 0.3 | 0.9 ± 0.3 | 0.9 ± 0.3 | 0.9 ± 0.3 |
| UA, mg/dL | 5.9 ± 1.7 | 5.7 ± 1.7 | 5.7 ± 1.6 | 5.5 ± 1.5 | 5.4 ± 1.4 | 5.3 ± 1.4 |
| Na, mEq/L | 142 ± 2 | 142 ± 2 | 142 ± 2 | 142 ± 3 | 142 ± 2 | 141 ± 3 |
| K, mEq/L | 4.3 ± 0.3 | 4.2 ± 0.3 | 4.2 ± 0.5 | 4.2 ± 0.4 | 4.1 ± 0.4 | 4.3 ± 0.4 |
| LDL-C, mg/dL | 97 ± 24 | 102 ± 26 | 97 ± 25 | 101 ± 25 | 105 ± 33 | 98 ± 28 |
| HDL-C, mg/dL | 60 ± 20 | 61 ± 17 | 60 ± 18 | 52 ± 14 | 54 ± 14 | 52 ± 13 |
| TG, mg/dL | 132 ± 132 | 124 ± 71 | 118 ± 74 | 147 ± 75 | 135 ± 87 | 137 ± 97 |
| FPG, mg/dL | 117 ± 31 | 120 ± 37 | 116 ± 24.5 | 121 ± 35 | 135 ± 38 | 120 ± 29 |
| HbA1c, % | 6.2 ± 0.9 | 6.2 ± 1.0 | 6.3 ± 0.9 | 5.9 ± 0.8 | 6.0 ± 0.8 | 6.1 ± 0.9 |
| BNP, pg/mL | 79 ± 95 | 74 ± 95 | 80 ± 93 | 53 ± 53 | 62 ± 76 | 66 ± 77 |