| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 8, Number 10, October 2016, pages 705-709
Budesonide Use and Hospitalization Rate in Crohn’s Disease: Results From a Cohort at a Tertiary Care IBD Referral Center
Tables
| Characteristic | No budesonide use (n = 664) | Budesonide use 1 - 90 days (n = 45) | Budesonide use > 90 days (n = 58) |
|---|---|---|---|
| DoD: duration of disease (years); DoO: duration of observation (years); SD: standard deviation. | |||
| Age in years, mean (SD) | 32.3 (13.6) | 32.9 (14.0) | 29.9 (11.5) |
| DoD (SD) | 12.5 (10.5) | 15.7 (15.5) | 17.6 (9.4) |
| DoO (SD) | 4.5 (3.2) | 5.8 (3.4) | 7.9 (3.2) |
| Race, % | |||
| Caucasian | 74.4 | 77.8 | 75.9 |
| African-American | 23.8 | 22.2 | 24.1 |
| Others | 1.8 | 0.0 | 0.0 |
| Sex, % | |||
| Female | 62.5 | 71.1 | 67.2 |
| Metabolic syndrome, % | 4.2 | 11.1 | 1.7 |
| Obesity, % | 19.6 | 17.8 | 17.2 |
| Immunomodulator use, % | 72.3 | 77.8 | 75.9 |
| Biological use, % | 49.9 | 57.8 | 37.9 |
| Thiopurine use, % | 50.8 | 55.6 | 63.8 |
| Methotrexate use, % | 10.5 | 8.9 | 13.8 |
| Budesonide use | CD-related number of hospitalizations/per 100-person years | Hospitalization rate (95% CI)* | IRR (95% CI) | ||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||
| *Per 100 person-years. Model 1 is unadjusted. Model 2 is partially adjusted for age, sex, race, and duration of disease. Model 3 is fully adjusted for age, sex, race, duration of disease, biologic and traditional immune modulators, diagnosis of metabolic syndrome, and obesity. CI: confidence interval; RR: rate ratio. | |||||
| No budesonide use | 924/3,012 | 30.68 (28.76 - 32.72) | 1 (reference) | 1 (reference) | 1 (reference) |
| Budesonide use 1 - 90 days | 68/263 | 25.86 (20.39 - 32.79) | 0.84 (0.66 - 1.08) | 0.97 (0.76 - 1.24) | 0.85 (0.65 - 1.10) |
| Budesonide use > 90 days | 89/457 | 19.47 (15.82 - 23.97) | 0.63 (0.51 - 0.79) | 0.67 (0.54 - 0.83) | 0.71 (0.56 - 0.91) |