J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 7, Number 10, October 2015, pages 795-801

Assessment of Myocardial Performance Index and Aortic Elasticity in Patients With Beta-Thalassemia Major

**Table 1.** Clinical, Hematological and Echocardiographic Parameters of Cases
	Thalassemia n (range)	Control	P
Age	20 (10 - 48)	20 (10 - 42)	0.808
Gender
Male, % (n)	58.7 (27)	41.3 (19)	0.558
Female, % (n)	52.8 (28)	47.2 (25)
Systolic blood pressure	100 (90 - 130)	110 (120 - 140)	< 0.001
Diastolic blood pressure	60 (50 - 70)	70 (60 - 90)	< 0.001
Pulse pressure	30 (30 - 60)	40 (25 - 60)	0.187
EF (%)	69 (53 - 79)	68 (60 - 83)	0.434
E/A ratio	1.957 ± 0.719	1.842 ± 0.666	0.418
E/E’ ratio	7.058 ± 2.15	6.076 ± 1.824	0.018
RWT	0.391 ± 0.067	0.372 ± 0.061	0.161
LA diameter (cm)	3.129 ± 0.458	2.761 ± 0.521	< 0.001
DTE (msn)	184.2 ± 49.261	214.16 ± 49.61	0.004
MAPSE	1.6 (1.2 - 1.9)	1.5 (1.2 - 1.8)	0.157
Hemoglobin	8.4 (6.5 - 10)	13.2 (12 - 16.2)	< 0.001
Platelet	398 (115 - 976)	247 (132 - 440)	< 0.001
Ferritin	785 (13 - 4,020)	25 (8 - 145)	< 0.001

Table 1. Clinical, Hematological and Echocardiographic Parameters of Cases

Thalassemia n (range)

Control

Age

20 (10 - 48)

20 (10 - 42)

0.808

Gender

Male, % (n)

58.7 (27)

41.3 (19)

0.558

Female, % (n)

52.8 (28)

47.2 (25)

Systolic blood pressure

100 (90 - 130)

110 (120 - 140)

< 0.001

Diastolic blood pressure

60 (50 - 70)

70 (60 - 90)

< 0.001

Pulse pressure

30 (30 - 60)

40 (25 - 60)

0.187

EF (%)

69 (53 - 79)

68 (60 - 83)

0.434

E/A ratio

1.957 ± 0.719

1.842 ± 0.666

0.418

E/E’ ratio

7.058 ± 2.15

6.076 ± 1.824

0.018

RWT

0.391 ± 0.067

0.372 ± 0.061

0.161

LA diameter (cm)

3.129 ± 0.458

2.761 ± 0.521

< 0.001

DTE (msn)

184.2 ± 49.261

214.16 ± 49.61

0.004

MAPSE

1.6 (1.2 - 1.9)

1.5 (1.2 - 1.8)

0.157

Hemoglobin

8.4 (6.5 - 10)

13.2 (12 - 16.2)

< 0.001

Platelet

398 (115 - 976)

247 (132 - 440)

< 0.001

Ferritin

785 (13 - 4,020)

25 (8 - 145)

< 0.001

**Table 2.** Results of Myocardial Performance Index and Aortic Elasticity Parameters in Thalassemia and Control Groups
	Thalassemia	Control	P
LV mass index	83.917 (50.62 - 144)	68.37 (41.9 - 113.3)	< 0.001
Myocardial performance index (g/m²)	0.464 (0.33 - 0.68)	0.431 (0.31 - 0.51)	0.006
Aortic strain	10.526 (3.7 - 33.3)	14.642 (7.69 - 35.29)	< 0.001
Aortic distensibility	5.797 (2 - 22.2)	8.333 (3.2 - 20.83)	< 0.001
Aortic stiffness index	4.257 (1.22 - 12.77)	2.775 (1.14 - 6.74)	< 0.001
Elastic modulus	3.45 (0.9 - 10)	2.4 (0.96 - 6.25)	< 0.001

Table 2. Results of Myocardial Performance Index and Aortic Elasticity Parameters in Thalassemia and Control Groups

Thalassemia

Control

LV mass index

83.917 (50.62 - 144)

68.37 (41.9 - 113.3)

< 0.001

Myocardial performance index (g/m²)

0.464 (0.33 - 0.68)

0.431 (0.31 - 0.51)

0.006

Aortic strain

10.526 (3.7 - 33.3)

14.642 (7.69 - 35.29)

< 0.001

Aortic distensibility

5.797 (2 - 22.2)

8.333 (3.2 - 20.83)

< 0.001

Aortic stiffness index

4.257 (1.22 - 12.77)

2.775 (1.14 - 6.74)

< 0.001

Elastic modulus

3.45 (0.9 - 10)

2.4 (0.96 - 6.25)

< 0.001

**Table 3.** Bivariate Correlation and Multiple Linear Regression Analysis Between Aortic Stiffness Index and Other Variables
Parameters	Bivariate analysis	Multiple linear regression analysis
Age	0.022	0.830
BMI	-0.077	0.447
Gender	-0.092	0.364
Thalassemia	-0.443	< 0.001	-0.729	0.041
Systolic BP	-0.040	0.691
Diastolic BP	0.205	0.042	0.164	0.154
Hemoglobin	-0.375	< 0.001	0.488	0.163
PLT	0.235	0.019	0.235	0.019
Ferritin	0.328	0.008	0.216	0.082

Table 3. Bivariate Correlation and Multiple Linear Regression Analysis Between Aortic Stiffness Index and Other Variables

Parameters

Bivariate analysis

Multiple linear regression analysis

Beta

Age

0.022

0.830

BMI

-0.077

0.447

Gender

-0.092

0.364

Thalassemia

-0.443

< 0.001

-0.729

0.041

Systolic BP

-0.040

0.691

Diastolic BP

0.205

0.042

0.164

0.154

Hemoglobin

-0.375

< 0.001

0.488

0.163

PLT

0.235

0.019

0.235

0.019

Ferritin

0.328

0.008

0.216

0.082

**Table 4.** Bivariate Correlation and Multiple Linear Regression Analysis Between Aortic Strain and Other Variables
Parameters	Bivariate analysis	Multiple linear regression analysis
Age	-0.130	0.200
BMI	0.045	0.660
Gender	0.114	0.261
Thalassemia	0.387	< 0.001	0.783	0.032
Systolic BP	0.022	0.832
Diastolic BP	-0.173	0.087
Hemoglobin	0.324	0.001	-0.563	0.116
PLT	-0.199	0.048	-0.199	0.048
Ferritin	-0.298	0.016	-0.203	0.110

Table 4. Bivariate Correlation and Multiple Linear Regression Analysis Between Aortic Strain and Other Variables

Parameters

Bivariate analysis

Multiple linear regression analysis

Beta

Age

-0.130

0.200

BMI

0.045

0.660

Gender

0.114

0.261

Thalassemia

0.387

< 0.001

0.783

0.032

Systolic BP

0.022

0.832

Diastolic BP

-0.173

0.087

Hemoglobin

0.324

0.001

-0.563

0.116

PLT

-0.199

0.048

-0.199

0.048

Ferritin

-0.298

0.016

-0.203

0.110

**Table 5.** Bivariate Correlation and Multiple Linear Regression Analysis Between Myocardial Performance Index and Other Variables
Parameters	Bivariate analysis	Multiple linear regression analysis
Age	0.127	0.212
BMI	-0.157	0.120
Gender	0.115	0.258
Thalassemia	-0.288	0.004	0.075	0.844
Systolic BP	0.004	0.966
Diastolic BP	0.011	0.915
Hemoglobin	-0.286	0.004	-0.353	0.342
PLT	0.196	0.052
Ferritin	0.242	0.052

Table 5. Bivariate Correlation and Multiple Linear Regression Analysis Between Myocardial Performance Index and Other Variables

Parameters

Bivariate analysis

Multiple linear regression analysis

Beta

Age

0.127

0.212

BMI

-0.157

0.120

Gender

0.115

0.258

Thalassemia

-0.288

0.004

0.075

0.844

Systolic BP

0.004

0.966

Diastolic BP

0.011

0.915

Hemoglobin

-0.286

0.004

-0.353

0.342

PLT

0.196

0.052

Ferritin

0.242

0.052