Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Case Report

Volume 7, Number 6, June 2015, pages 490-494

Immune-Mediated Necrotizing Myopathy, Associated With Antibodies to Signal Recognition Particle, Together With Lupus Nephritis: Case Presentation and Management


Figure 1.
Figure 1. (a) Scattered, angulated and rounded, atrophic fibers (H&E, cryostat section). (b) Large numbers of necrotic and basophilic regenerating fibers (H&E, paraffin section). (c) Necrotic fibers occurring singly and in small groups, many showing myophagocytosis (H&E, cryostat section). (d) Small numbers of CD8+ T lymphocytes, mostly confined to perivascular locations (CD8 immunohistochemistry). (e) Macrophages within necrotic fibers (CD68 immunohistochemistry). (f) Patchy sarcolemmal upregulation of MHC class I antigen (MHC class I immunohistochemistry).