Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 2, Number 3, June 2010, pages 121-126


Sensitivity, Specificity, Negative and Positive Predictive Values of Adenosine Deaminase in Patients of Tubercular and Non-Tubercular Serosal Effusion in India

Tables

Table 1. Reference Values of ADA in Various Body Fluids (U/L)
 
Type of FluidNegativePositive
Serum/plasma/Pleural/Ascitic/synovial Fluids40 or < 40> 40
CSF10 or < 10> 10

 

Table 2. Table Showing Distribution of Cases According to the Initial Set Criteria
 
Type of DiseaseAspirated FluidEtiology;
According to Set Criteria
Number of Cases
1. PulmonaryPleural (n = 72)Tuberculous42
Non tuberculous30
2. Extra-PulmonaryAscitic / Peritoneal (n = 108)Tuberculous36
Non tuberculous72
CSF (n = 120)Tuberculous54
Non tuberculous66
Synovial (n = 30)Tuberculous21
Non tuberculous09
Total330

 

Table 3. Table Showing ADA and AFB Positivity in Tubercular Group
 
Type of Tubercular DiseaseAspirated FluidEtiology; No. of Tubercular Cases According to Set CriteriaAFB Positive Cases
Pulmonary (n = 42)Pleural (n = 72)4214
Extra-Pulmonary (n = 111)Ascitic/Peritoneal (n = 108)3609
CSF (n = 120)54nil
Synovial (n = 30)21nil
Total15323

 

Table 4. Table Showing Range of ADA With Median Corresponding to Etiology
 
Type of FluidCut OffRange U/LMedian
Pleural> 4040.4 - 13688
≤ 404.8 - 3821.5
Ascitic/Peritoneal> 4048 - 180110
≤ 403.3 - 4016
Synovial> 4046 - 15688
≤ 4025 - 32.627.2
CSF> 1010.2 - 11024
≤ 102 - 106.4

 

Table 5. Sensitivity, Specificity, Negative and Positive Predictive Values of ADA Estimation in Different Groups
 
Type of DiseaseAspirated FluidEtiology According to Set CriteriaCut Off Value of ADANumber of True Positive/Negative CasesSensitivity %Specificity %Positive Predictive Value %Negative Predictive Value %
Pulmonary (n = 72)Pleural (n = 72)Tuberculous (n = 42)> 403992.8090.0092.8690.00
Non-tuberculous (n = 30)≤ 4027
Extra-Pulmonary (n = 258)Over all includes;Tuberculous (n = 111)> 40 / 109994.2992.1689.0095.92
Non-tuberculous (n = 147)≤ 40 / 10141
Ascitic (n = 108)Tuberculous (n = 36)> 40331009691.67100.00
Non-tuberculous (n = 72)≤ 4072
Synovial (n = 30)Tuberculous (n = 21)> 401885.7166.6785.7166.67
Non-tuberculous (n = 09)≤ 4006
CSF (n = 120)Tuberculous (n = 54)> 104884.1291.3088.8995.46
Non-tuberculous (n = 66)≤ 1063