Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 2, Number 2, April 2010, pages 79-84

Role of Adenosine Deaminase Estimation in Differentiation of Tuberculous and Non-tuberculous Exudative Pleural Effusions

Tables

Table 1. Distribution of the Cases According to Accepted Criteria
 
GroupDiseaseNumber of Cases
Tuberculosis (n = 56)Tuberculosis56
Non-Tuberculosis (n = 40)Malignancy16
Infectious diseases18
Pulmonary embolism1
Collagen vascular disease3
Sarcoidosis2

 

Table 2. Biochemical Parameters in Pleural Fluid in Different Groups
 
GroupDiseasepHGlucose mg%Protein g%LDH U/L
Tubercular (n = 56)Tuberculosis (n = 56)7.31 ± 0.0946.2 ± 17.64.3 ± 0.9151.6 ± 27.0
Non-Tubercular (n = 40)Malignant (n = 16)7.32 ± 0.0742.2 ± 19.64.2 ± 1.1147.4 ± 18.6
Infectious diseases (n = 18)7.31 ± 0.0831.4 ± 17.84.1 ± 1.2141.7 ± 23.1
Pulmonary embolism (n = 1)7.2940.73.9136.0
Collage Vascular Disease (n = 3)7.27 ± 0.0551.5 ± 14.64.4 ± 0.7154.6 ± 13.7
Sarcoidosis (n = 2)7.32 ± 0.0358.8 ± 18.94.2 ± 0.9148.6 ± 11.6

 

Table 3. ADA Range With Mean ± SD in Different Groups
 
GroupDiseaseRangeMean ± SD
Tubercular (n = 56)TB (n = 56)115.4 (40.6 - 156.0)67.34 ± 22.85
Non-Tubercular (n = 40)Over all33.2 (4.8 - 38.0)18.60 ± 9.12
Malignant (n = 16)26.6 (6.4 - 33.0)9.08 ± 9.96
Infectious diseases (n = 18)27.2 (4.8 - 32.0)18 ± 7.83
Pulmonary embolism (n = 1)13.58--
Collagen Vascular Disease (n = 3)5 (10.0 - 5.0)12 ± 2.65
Sarcoidosis (n = 2)8 (30.0 - 38.0)34 ± 5.66

 

Table 4. Pleural Fluid ADA Levels With Their Significance
 
GroupNumber of CasesADA Levels in U/LTrue Positive / Negative CasesMean ± SDz calP-value
*p < 0.01 shows a highly significant difference between the tuberculous and non-tuberculous groups.
Tuberculous56> 405667.34 ± 22.8514.480.0007 (p < 0.01)*
≤ 4000
Non-tuberculous40> 400118.60 ± 9.12
≤ 4039
Total9696