J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 1, Number 4, October 2009, pages 202-206

Residual Cognitive Deficit in Adults with Depression who Recovered after 6-month Treatment: Stable versus State-Dependent Markers

**Table 1.** Demographic data and HAM-D scores for MDD patients and controls
	MDD patients	Normal controls	‡Z	p value
†HAM-D-17:17-item Hamilton Rating Scale for Depression‡Mann-Whitney Test was used to compare the ages and HAM-D scores in both groupsCross table chi-square was used to compare the sex and education level
Sex						0.69
Male		4		6
Female		9		7
Education level						0.22
Below junior high school		3		0
Above junior high school		10		13
Age	37.19 ± 12.62	13	38.92 ± 12.61	13	-0.51	0.61
†HAM-D-17	23.23 ± 6.10	13	0.38 ± 0.51	13	-4.41	< 0.01

Table 1. Demographic data and HAM-D scores for MDD patients and controls

MDD patients

Normal controls

‡Z

p value

Mean ± SD

†HAM-D-17:17-item Hamilton Rating Scale for Depression‡Mann-Whitney Test was used to compare the ages and HAM-D scores in both groupsCross table chi-square was used to compare the sex and education level

Sex

0.69

Male

Female

Education level

0.22

Below junior high school

Above junior high school

Age

37.19 ± 12.62

38.92 ± 12.61

-0.51

0.61

†HAM-D-17

23.23 ± 6.10

0.38 ± 0.51

-4.41

< 0.01

**Table 2.** HAM-D scores and neurocognitive measures for MDD patients and controls
	MDD Assessment I	MDD Assessment II	Normal Controls	‡Assessment I	‡Assessment II	§ Assessment I
†HAM-D-17:17-item Hamilton Rating Scale for Depression; WMS-R: Wechsler Memory ScaleRevised; CPT: Continuous Performance Test; FTT: Finger Tapping Test; WCST: Wisconsin Card-Sorting test‡Mann-Whitney Test§Wilcoxon signed ranks test
†HAM-D-17	23.23 ± 6.10	13	2.38 ± 2.84	13	0.38 ± 0.51	13	-4.41	< 0.01	-1.91	0.06	-3.18	< 0.01
†WMS-R
Verbal MEM.	81.33 ± 16.90	13	90.38 ± 15.23	13	96.18 ± 9.26	13	-2.53	< 0.05	-1.54	0.13	-2.33	< 0.05
Visual MEM.	78.92 ± 22.63	13	106.13 ± 20.99	13	111.18 ± 16.56	13	-2.93	< 0.01	-0.74	0.46	-2.52	< 0.05
General MEM.	76.08 ± 22.27	13	93.75 ± 14.92	13	100.55 ± 11.03	13	-2.90	< 0.01	-1.49	0.14	-2.38	< 0.05
Attention/Concentration	91.75 ± 18.22	13	99.70 ± 16.79	13	104.00 ± 14.13	13	-2.34	< 0.05	-1.14	0.25	-2.02	< 0.05
Delayed Recall	82.42 ± 22.67	13	102.25 ± 17.69	13	104.00 ± 15.40	13	-2.40	< 0.05	-0.37	0.71	-2.38	< 0.05
†FTT
Dominant hand	30.69 ± 15.03	13	31.99 ± 16.46	13	59.24 ± 10.85	13	-3.59	< 0.01	-3.3.2	<0.01	-1.61	0.11
†WCST
Perseverative Errors	10.50 ± 4.36	13	9.42 ± 3.40	13	4.50 ± 7.12	13	-2.37	< 0.05	-2.10	<0.05	-1.53	0.13
†CPT
d’ Masked	3.01 ± 0.94	13	3.47 ± 0.93	13	3.88 ± 0.64	13	-2.32	< 0.05	-1.00	0.32	-2.51	< 0.05

Table 2. HAM-D scores and neurocognitive measures for MDD patients and controls

MDD Assessment I

MDD Assessment II

Normal Controls

‡Assessment I

‡Assessment II

§ Assessment I

vs.

Normal Controls

Assessment II

Mean ± SD

p value

Sig.

p value

†HAM-D-17:17-item Hamilton Rating Scale for Depression; WMS-R: Wechsler Memory ScaleRevised; CPT: Continuous Performance Test; FTT: Finger Tapping Test; WCST: Wisconsin Card-Sorting test‡Mann-Whitney Test§Wilcoxon signed ranks test

†HAM-D-17

23.23 ± 6.10

2.38 ± 2.84

0.38 ± 0.51

-4.41

< 0.01

-1.91

0.06

-3.18

< 0.01

†WMS-R

Verbal MEM.

81.33 ± 16.90

90.38 ± 15.23

96.18 ± 9.26

-2.53

< 0.05

-1.54

0.13

-2.33

< 0.05

Visual MEM.

78.92 ± 22.63

106.13 ± 20.99

111.18 ± 16.56

-2.93

< 0.01

-0.74

0.46

-2.52

< 0.05

General MEM.

76.08 ± 22.27

93.75 ± 14.92

100.55 ± 11.03

-2.90

< 0.01

-1.49

0.14

-2.38

< 0.05

Attention/Concentration

91.75 ± 18.22

99.70 ± 16.79

104.00 ± 14.13

-2.34

< 0.05

-1.14

0.25

-2.02

< 0.05

Delayed Recall

82.42 ± 22.67

102.25 ± 17.69

104.00 ± 15.40

-2.40

< 0.05

-0.37

0.71

-2.38

< 0.05

†FTT

Dominant hand

30.69 ± 15.03

31.99 ± 16.46

59.24 ± 10.85

-3.59

< 0.01

-3.3.2

<0.01

-1.61

0.11

†WCST

Perseverative Errors

10.50 ± 4.36

9.42 ± 3.40

4.50 ± 7.12

-2.37

< 0.05

-2.10

<0.05

-1.53

0.13

†CPT

d’ Masked

3.01 ± 0.94

3.47 ± 0.93

3.88 ± 0.64

-2.32

< 0.05

-1.00

0.32

-2.51

< 0.05