Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 6, Number 6, December 2014, pages 414-421


Importance of Pre-Transplant Colonoscopy in Renal Transplant Recipients

Figures

Figure 1.
Figure 1. Percentage of patients with at least one lesion found at specific colon sites. (a) All colonoscopies. (b) Screening colonoscopies. (c) Patients under age of 50.
Figure 2.
Figure 2. Localization of lesions (in %) in patients with polyps.

Tables

Table 1. Characteristics of Patients and Comparison of Groups With and Without a Colonoscopy 5 Years or Less Before Transplant
 
Global population % (n = 159)Colonoscopy % (n = 64)No colonoscopy % (n = 95)P value
P value: comparison between “colonoscopy” and “no colonoscopy”.
Male64.2 (102)75 (48)56.8 (54)< 0.05
Age at transplant (years), mean and standard deviation48.1 (SD 12.5)55.6 (SD 8.7)43.1 (SD 12.1)< 0.05
≥ 50 years old48.4 (77)70.3 (45)33.7 (32)< 0.01
Body mass index (kg/m2), mean and standard deviation26.3 (SD 5.5)28.3 (5.3)24.9 (5.3)< 0.01
Type II diabetes15.7 (25)29.7 (19)6.3 (6)< 0.01
Diabetic nephropathy13.2 (21)23.4 (15)6.3 (6)< 0.05
Dyslipidemia treated with statins49.1 (78)60.9 (39)41.1 (39)< 0.05
Dialysis88.7 (141)90.6 (58)87.4 (83)0.70
Immunosuppressive use14.5 (23)17.2 (11)12.6 (12)0.57

 

Table 2. Comparison Between Patients With and Without Polyps
 
Polyps n = 21 (%)No polyps n = 43 (%)P value
Male76.2 (16)74.4 (32)0.88
Age at transplant (years), mean and standard deviation57.3 (SD 6.5)54.8 (SD 9.5)0.21
≥ 50 years old76.2 (16)76.7 (33)0.96
Body mass index (kg/m2), mean and standard deviation27.6 (SD 5.2)28.7 (SD 5.4)0.47
Type II diabetes28.6 (6)30.2 (13)0.88
Diabetic nephropathy28.6 (6)20.9 (9)0.54
Dyslipidemia treated with statins57.1 (12)62.8 (27)0.87
Dialysis90.5 (19)90.7 (39)0.98
Time elapsed between start of dialysis and colonoscopy and standard deviation2.40 (SD 3.17)1.90 (SD 2.98)0.62
95% CI (0.65 - 4.16)95% CI (0.7 - 3.10)
Immunosuppressive use9.5 (2)20.9 (9)0.43

 

Table 3. Colonoscopies According to Patient’s Age
 
Colonoscopies in < 50 years old (n = 19)Colonoscopies in ≥ 50 years old (n = 45)
There were no statistically significant differences between the groups.
Screening colonoscopy % (n = 45)57.9 (11)75.6 (34)
% of patients with polyps (n = 21)26.3 (5)35.6 (16)
Adenomas % (n = 14)15.8 (3)24.4 (11)

 

Table 4. Endoscopic and Pathologic Results
 
All patient with a colonoscopy % (n = 64)Screening colonoscopies % (n = 45)Diagnostic colonoscopies % (n = 19)Patients with polyps % (n = 21)
% of patients with polyps32.8 (21)33.3 (15)31.6 (6)100 (21)
Polyps ≥ 10 mm6.3 (4)6.7 (3)5.3 (1)21.1 (4)
Adenomas21.9 (14)24.4 (11)15.8 (3)66.7 (14)
Hyperplastic polyps4.7 (3)4.4 (2)5.3 (1)9.5 (2)
Unknown pathology6.3 (4)4.4 (2)10.5 (2)19 (4)
Patients with multiple polyps (≥ 2)20.3 (13)20 (9)21.1 (4)61.9 (13)
Patients with only distal polyps10.3 (7)15.6 (7)033.3 (7)
Patients with only proximal polyps10.3 (7)8.9 (4)15.8 (3)33.3 (7)
Patients with synchronous polyps10.3 (7)8.9 (4)15.3 (3)33.3 (7)
Diverticulosis40.6 (26)46.7 (21)26.3 (5)33.3 (7)
Angiodysplasia4.7 (3)4.4 (2)5.3 (1)4.8 (1)