Figure 1. Individual plot of mean systolic blood pressure (SBP) at baseline and 12 weeks after the commencement of fixed-dose combination of losartan/hydrochlorothiazide; (A), daytime; (B), nighttime.
| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 6, Number 1, February 2014, pages 8-16
The Fixed-Dose Combination of Losartan/Hydrochlorothiazide Elicits Potent Blood Pressure Lowering During Nighttime in Obese Hypertensive Patients
Figure
Tables
| BP: blood pressure; BNP: B-type natriuretic peptide; eGFR: estimated glomerular filtration rate; ARB: angiotensin receptor blocker. | |
| Gender (male %) | 54 (50%) |
| Office BP, mmHg | |
| systolic | 158 ± 12 |
| diastolic | 82 ± 8 |
| Diabetes (%) | 20 (18%) |
| Age, years | 66.0 ± 9.7 |
| Smoking (%) | 27 (25%) |
| History of hypertension, years | 6.5 ± 4.8 |
| Body mass index | 26.4 ± 3.7 |
| Left ventricular hypertrophy on ECG (%) | 54 (50%) |
| Left ventricular ejection fraction, % | 69 ± 6 |
| BNP, pg/mL | 60 ± 61 |
| eGFR, mL/min/1.73m2 | 73 ± 23 |
| Co-prescription | |
| Calcium channel blocker (%) | 64 (59%) |
| Statin (%) | 35 (32%) |
| Previous ARB | |
| Losartan | 14 |
| Valsartan | 36 |
| Candesartan | 26 |
| Telmisartan | 22 |
| Olmesartan | 15 |
| Baseline | 12 weeks | P | |
|---|---|---|---|
| SBP, systolic blood pressure; DBP, diastolic blood pressure; UA, uric acid; eGFR, estimated glomerular filtration rate; BNP, B-type natriuretic peptide. | |||
| ABPM parameters; | |||
| Daytime | |||
| SBP, mmHg | 151 ± 14 | 140 ± 11 | P < 0.001 |
| DBP, mmHg | 88 ± 8 | 82 ± 8 | P < 0.001 |
| Pulse rate, /min | 70 ± 7 | 71 ± 9 | NS |
| Nighttime | |||
| SBP, mmHg | 138 ± 18 | 125 ± 14 | P < 0.001 |
| DBP, mmHg | 78 ± 9 | 72 ± 9 | P < 0.001 |
| Pulse rate, /min | 60 ± 8 | 61 ± 8 | NS |
| Nocturnal SBP dipping, % | 8.5 ± 11 | 10.8 ± 8.8 | P < 0.1 |
| Nocturnal minimum SBP, mmHg | 134 ± 18 | 117 ± 15 | P < 0.001 |
| Morning SBP, mmHg | 156 ± 20 | 144 ± 15 | P < 0.001 |
| Laboratory data | |||
| Serum potassium, mEq/L | 4.3 ± 0.4 | 4.1 ± 0.4 | P < 0.001 |
| Serum UA, mg/dL | 5.7 ± 1.1 | 5.6 ± 0.9 | NS |
| eGFR, ml/min/1.73m2 | 73 ± 23 | 69 ± 18 | P < 0.1 |
| Plasma BNP, pg/mL | 60 ± 61 | 38 ± 30 | P < 0.001 |