J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 5, Number 1, February 2013, pages 34-41

Nanoduct Sweat Conductivity Measurements in 2664 Patients: Relationship to Age, Arterial Blood Gas, Serum Electrolyte Profiles and Clinical Diagnosis

**Table 1.** The Distribution of the Number of Patients was Based on the 1st and 2nd Conductivity Results, and the Numbers in Parantheses Represent the Cystic Fibrosis Patients Confirmed by the Sweat Chloride Measurements
			2nd conductivity test (mmol/L)
	3 - 60 Normal	2,588	35	0	1 (1 CF)
1st conductivity test (mmol/L)	61 - 80 Intermediate	0	17	6 (4 CF)	1 (1 CF)
	> 80 Positive	0	4	1	11 (11 CF)

Table 1. The Distribution of the Number of Patients was Based on the 1st and 2nd Conductivity Results, and the Numbers in Parantheses Represent the Cystic Fibrosis Patients Confirmed by the Sweat Chloride Measurements

2nd conductivity test (mmol/L)

3 - 60 Normal

61 - 80 Intermediate

> 80 Positive

3 - 60 Normal

2,588

1 (1 CF)

1st conductivity test (mmol/L)

61 - 80 Intermediate

6 (4 CF)

1 (1 CF)

> 80 Positive

11 (11 CF)

**Table 2.** The Conductivity Measurements in Patients According to Age Groups
		All Ages (n)	0 - 6 months	7 - 12 months	13 - 24 months	> 24 months
	Mean ± SD	34.26 ± 10.34	34.58 ± 14.34	34.79 ± 11.47	32.86 ± 9.83	32.18 ± 8.44	33.47 ± 8.75	33.33 ± 8.14	35.38 ± 10.07	35.61 ± 9.15
1st conductivity test, mmol/L		(2,664)	(366)	(206)	(337)	(204)	(363)	(227)	(534)	(427)
	Min - Max	5 - 131	12 - 131	10 - 91	5 - 110	11 - 62	9 - 80	12 - 58	7 - 106	6 - 77
	Mean ± SD	48.74 ± 22.55	52.41 ± 24.54	45.86 ± 23.11	32.86 ± 9.83	27.67 ± 16.56	44.88 ± 19.08		54.80 ± 23.05	41.12 ± 7.64
2nd conductivity test, mmol/L		(76)	(29)	(14)	(4)	(3)	(8)	(0)	(10)	(8)
	Min - max	12 - 99	17 - 98	12 - 87	31 - 99	12 - 45	24 - 84		31 - 98	32 - 51

Table 2. The Conductivity Measurements in Patients According to Age Groups

All Ages (n)

0 - 6 months

7 - 12 months

13 - 24 months

> 24 months

Male (n)

Female (n)

Male (n)

Female (n)

Male (n)

Female (n)

Male (n)

Female (n)

Mean ± SD

34.26 ± 10.34

34.58 ± 14.34

34.79 ± 11.47

32.86 ± 9.83

32.18 ± 8.44

33.47 ± 8.75

33.33 ± 8.14

35.38 ± 10.07

35.61 ± 9.15

1st conductivity test, mmol/L

(2,664)

(366)

(206)

(337)

(204)

(363)

(227)

(534)

(427)

Min - Max

5 - 131

12 - 131

10 - 91

5 - 110

11 - 62

9 - 80

12 - 58

7 - 106

6 - 77

Mean ± SD

48.74 ± 22.55

52.41 ± 24.54

45.86 ± 23.11

32.86 ± 9.83

27.67 ± 16.56

44.88 ± 19.08

54.80 ± 23.05

41.12 ± 7.64

2nd conductivity test, mmol/L

(76)

(29)

(14)

(4)

(3)

(8)

(0)

(10)

(8)

Min - max

12 - 99

17 - 98

12 - 87

31 - 99

12 - 45

24 - 84

31 - 98

32 - 51

**Table 3.** Different Conductivity Cut-off Values of the 1st and 2nd Tests to Predict the Cystic Fibrosis Diagnosis, According to the Number of Patients Confirmed by Sweat Chloride Measurements
		Sensitivity (%)	Specificity (%)	Area Under Cure
1st conductivity test	53 mmol/L	100	100	0.647 P > 0.05
58 mmol/L	94	100
63 mmol/L	88	100
2nd conductivity test	60 mmol/L	100	100	1 P < 0.007
61.5 mmol/L	100	66

Table 3. Different Conductivity Cut-off Values of the 1st and 2nd Tests to Predict the Cystic Fibrosis Diagnosis, According to the Number of Patients Confirmed by Sweat Chloride Measurements

Sensitivity (%)

Specificity (%)

Area Under Cure

1st conductivity test

53 mmol/L

100

0.647
P > 0.05

58 mmol/L

100

63 mmol/L

100

2nd conductivity test

60 mmol/L

100

1
P < 0.007

61.5 mmol/L

100

**Table 4.** The Distribution of Laboratory Values Based on Conductivity Results and the Results of the Patients Diagnosed With Cystic Fibrosis. A Comparison of laboratory Values Based on Normal, Intermediate and Positive Conductivity are Also Given (ANOVA)
		3 - 60 mmol/L	61 - 80 mmol/L	> 80 mmol/L	CF Patients	ANOVA
Na	Mean ± SD	138.42 ± 3.75	137.72 ± 3.80	130.21 ± 5.64	133.43 ± 6.2	17.1	< 0.001
Median	139	137.5	131	134
Min - Max	123 - 163	131 - 142	120 - 137	118 - 142
K	Mean ± SD	4.53 ± 0.71	4.45 ± 0.38	3.67 ± 0.56	4 ± 0.6	4.57	0.01
Median	4.5	4.5	3.5	4.15
Min - Max	2.3 - 7.3	3.9 - 5.2	3.1 - 4.5	3.1 - 4.7
Cl	Mean ± SD	103.29 ± 4.30	102.96 ± 4.52	88.43 ± 17.23	93.9 ± 15.5	35.85	< 0.001
Median	104	103	88	101
Min - Max	80 - 138	94 - 109	64 - 106	64 - 108
pH	Mean ± SD	7.39 ± 0.7	7.39 ± 0.06	7.5 ± 0.12	7.47 ± 0.11	8.33	< 0.001
Median	7.39	7.39	7.51	7.45
Min - Max	7.0 - 7.6	7.3 - 7.5	7.3 - 7.7	7.3 - 7.7
pCO₂	Mean ± SD	37.35 ± 8.31	36.31 ± 7.77	38.21 ± 8.68	37.96 ± 6.9	0.10	0.89
Median	36	38.5	40.4	40
Min - Max	20.6 - 102.1	23.9 - 46.2	21 - 48	23.9 - 48
HCO₃	Mean ± SD	22.17 ± 4.32	22 ± 3.86	30.64 ± 14.58	28.37 ± 12.8	11.98	< 0.001
Median	21.6	22.3	25.5	25.5
Min - Max	9.6 - 43.4	15.6 - 27.6	17.6 - 54	15.6 - 54

Table 4. The Distribution of Laboratory Values Based on Conductivity Results and the Results of the Patients Diagnosed With Cystic Fibrosis. A Comparison of laboratory Values Based on Normal, Intermediate and Positive Conductivity are Also Given (ANOVA)

3 - 60 mmol/L

61 - 80 mmol/L

> 80 mmol/L

CF Patients

ANOVA

Normal

Intermediate

Positive

(n: 509)

(n: 9)

(n: 7)

(n: 17)

Mean ± SD

138.42 ± 3.75

137.72 ± 3.80

130.21 ± 5.64

133.43 ± 6.2

17.1

< 0.001

Median

139

137.5

131

134

Min - Max

123 - 163

131 - 142

120 - 137

118 - 142

Mean ± SD

4.53 ± 0.71

4.45 ± 0.38

3.67 ± 0.56

4 ± 0.6

4.57

0.01

Median

4.5

3.5

4.15

Min - Max

2.3 - 7.3

3.9 - 5.2

3.1 - 4.5

3.1 - 4.7

Mean ± SD

103.29 ± 4.30

102.96 ± 4.52

88.43 ± 17.23

93.9 ± 15.5

35.85

< 0.001

Median

104

103

101

Min - Max

80 - 138

94 - 109

64 - 106

64 - 108

Mean ± SD

7.39 ± 0.7

7.39 ± 0.06

7.5 ± 0.12

7.47 ± 0.11

8.33

< 0.001

Median

7.39

7.51

7.45

Min - Max

7.0 - 7.6

7.3 - 7.5

7.3 - 7.7

pCO₂

Mean ± SD

37.35 ± 8.31

36.31 ± 7.77

38.21 ± 8.68

37.96 ± 6.9

0.10

0.89

Median

38.5

40.4

Min - Max

20.6 - 102.1

23.9 - 46.2

21 - 48

23.9 - 48

HCO₃

Mean ± SD

22.17 ± 4.32

22 ± 3.86

30.64 ± 14.58

28.37 ± 12.8

11.98

< 0.001

Median

21.6

22.3

25.5

Min - Max

9.6 - 43.4

15.6 - 27.6

17.6 - 54

15.6 - 54