J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 9, Number 10, October 2017, pages 838-843

Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

**Table 1.** Demographic and Clinical Characteristics of Patients
Variable	Group I (MAU negative) (n = 62)	Group II (MAU positive) (n = 28)	P-value
Numerical data expressed as median ± IQR. CAD: coronary artery disease.
Age (years)	53 ± 3.25	54 ± 2.75	0.100
Sex			0.994
Males, n (%)	40 (64.5%)	19 (67.9%)
Females, n (%)	22 (35.5%)	9 (32.1% )
Hypertension, n (%)	38 (61.2%)	17 (60%)	0.998
Hypercholesterolemia, n (%)	22 (35.4%)	10 (35.7%)	0.513
Smokers, n (%)	21 (33.8%)	9 (32.1%)	0.999
Family history of CAD, n (%)	7 (11.3%)	3 (10.7%)	0.999
Fasting blood sugar (mg/dL)	86 ± 4	85 ± 3.75	0.499
Serum creatinine (mg/dL)	1.07 ± 0.062	1.08 ± 0.047	0.254

Table 1. Demographic and Clinical Characteristics of Patients

Variable

Group I (MAU negative) (n = 62)

Group II (MAU positive) (n = 28)

P-value

Numerical data expressed as median ± IQR. CAD: coronary artery disease.

Age (years)

53 ± 3.25

54 ± 2.75

0.100

Sex

0.994

Males, n (%)

40 (64.5%)

19 (67.9%)

Females, n (%)

22 (35.5%)

9 (32.1% )

Hypertension, n (%)

38 (61.2%)

17 (60%)

0.998

Hypercholesterolemia, n (%)

22 (35.4%)

10 (35.7%)

0.513

Smokers, n (%)

21 (33.8%)

9 (32.1%)

0.999

Family history of CAD, n (%)

7 (11.3%)

3 (10.7%)

0.999

Fasting blood sugar (mg/dL)

86 ± 4

85 ± 3.75

0.499

Serum creatinine (mg/dL)

1.07 ± 0.062

1.08 ± 0.047

0.254

**Table 2.** Prevalence of Single Vessel, Double Vessel and Triple Vessel CAD
No. of vessel involved	Group I (MAU negative) (n = 62)	Group II (MAU positive) (n = 28)	P-value*
*P < 0.05 was considered significant.
Single vessel, n (%)	39 (62.9%)	3 (10.7%)	< 0.001
Double vessel, n (%)	15 (24.1%)	13 (46.4%)	0.033
Triple vessel, n (%)	8 (12.9%)	12 (42.8%)	0.002

Table 2. Prevalence of Single Vessel, Double Vessel and Triple Vessel CAD

No. of vessel involved

Group I (MAU negative) (n = 62)

Group II (MAU positive) (n = 28)

P-value*

*P < 0.05 was considered significant.

Single vessel, n (%)

39 (62.9%)

3 (10.7%)

< 0.001

Double vessel, n (%)

15 (24.1%)

13 (46.4%)

0.033

Triple vessel, n (%)

8 (12.9%)

12 (42.8%)

0.002

**Table 3.** Correlation Between Microalbuminuria and Number of Vessels Affected
Group	SVD, n (%)	DVD, n (%)	TVD, n (%)	r*; P-value
MAU: microalbuminuria; CAD: coronary artery disease; SVD: single vessel disease; DVD: double vessel disease; TVD: triple vessel disease. r* = Spearman rho correlation coefficient.
Group I (MAU negative) (n = 62)	39 (62.9%)	15 (24.1%)	8 (12.9%)	r = - 0.035; P = 0.785
Group II (MAU positive) (n = 28)	3 (10.7%)	13 (46.4%)	12 (42.8%)	r = 0.094; P < 0.001

Table 3. Correlation Between Microalbuminuria and Number of Vessels Affected

Group

SVD, n (%)

DVD, n (%)

TVD, n (%)

r*; P-value

MAU: microalbuminuria; CAD: coronary artery disease; SVD: single vessel disease; DVD: double vessel disease; TVD: triple vessel disease. r* = Spearman rho correlation coefficient.

Group I (MAU negative) (n = 62)

39 (62.9%)

15 (24.1%)

8 (12.9%)

r = - 0.035; P = 0.785

Group II (MAU positive) (n = 28)

3 (10.7%)

13 (46.4%)

12 (42.8%)

r = 0.094; P < 0.001

**Table 4.** The Median ACR Level Among Patients With SVD, DVD and TVD in Group II
Vessel affected	ACR level (median)	P-value
*P < 0.05 was considered significant. In all comparisons (SVD vs. DVD, SVD vs. TVD, DVD vs. TVD), P value was significant.
SVD	121	< 0.001 (between all comparison)*
DVD	131
TVD	146

Table 4. The Median ACR Level Among Patients With SVD, DVD and TVD in Group II

Vessel affected

ACR level (median)

P-value

*P < 0.05 was considered significant. In all comparisons (SVD vs. DVD, SVD vs. TVD, DVD vs. TVD), P value was significant.

SVD

121

< 0.001 (between all comparison)*

DVD

131

TVD

146

**Table 5.** Median SYNTAX Score Between the Two Groups
	SYNTAX score, median ± IQR	P-value
MAU: microalbuminuria; IQR: interquartile range. P < 0.05 was considered significant.
Group I (MAU negative) (n = 62)	21 ± 6	< 0.001
Group II (MAU positive) (n = 28)	28 ± 8

Table 5. Median SYNTAX Score Between the Two Groups

SYNTAX score, median ± IQR

P-value

MAU: microalbuminuria; IQR: interquartile range. P < 0.05 was considered significant.

Group I (MAU negative) (n = 62)

21 ± 6

< 0.001

Group II (MAU positive) (n = 28)

28 ± 8

**Table 6.** Relation Between SYNTAX Score and ACR
Urinary ACR	SYNTAX ≤ 22, n (%)	SYNTAX > 22, n (%)	P-value
ACR: albumin/creatinine ratio. P < 0.05 was considered significant. Also, when group I and group II where compared, patients with MAU had higher SYNTAX scores compared to those without MAU (P < 0.001).
Group I	45 (72.5%)	17 (27.4%)	< 0.001 (both groups)
Group II	6 (21.4%)	22 (78.5%)

Table 6. Relation Between SYNTAX Score and ACR

Urinary ACR

SYNTAX ≤ 22, n (%)

SYNTAX > 22, n (%)

P-value

ACR: albumin/creatinine ratio. P < 0.05 was considered significant. Also, when group I and group II where compared, patients with MAU had higher SYNTAX scores compared to those without MAU (P < 0.001).

Group I

45 (72.5%)

17 (27.4%)

< 0.001 (both groups)

Group II

6 (21.4%)

22 (78.5%)