Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Review

Volume 7, Number 10, October 2015, pages 731-741


Effects of Anesthetic Management on Early Postoperative Recovery, Hemodynamics and Pain After Supratentorial Craniotomy

Tables

Table 1. The Aldrete Score [12]
 
Activity
  2Able to move spontaneously or on command four extremities
  1Able to move voluntarily or on command two extremities
  0Unable to move any extremities
Respiration
  2Able to deep breath and cough freely
  1Dyspnea, shallow or limited breathing
  0Apneic
Circulation
  2BP + 20 mm Hg of pre-sedation level
  1BP + 20 - 50 mm Hg of pre-sedation level
  0BP + 50 mm Hg of pre-sedation level
Consciousness
  2Fully awake
  1Arousable on calling
  0Not responding
Skin color
  2Normal
  1Pale, dusky, blotchy, jaundiced, other
  0Cyanotic

 

Table 2. Early Postoperative Recovery and Effects of Balanced Inhalational Versus Total Intravenous Anesthesia [11-14, 16, 17, 23, 24]
 
StudiesDrugsClinical variablesResults
ET: extubation time; TEO: time to eyes opening; GCS: Glasgow coma scale; VAS: visual analogue scale; SOMCT: short orientation memory concentration test.
Lauta et al, 2010 [11]Sevoflurne/remifentanil vs. propofol/remifentanilAldrete score
TEO
ET
No clinical differences
Ravussin et al, 1991 [24]Thiopental/isoflurane vs. propofolGSCPropofol group had higher GSC score in early recovery
Todd et al, 1993 [12]Propofol/fentanyl vs. isoflurane/nitrous oxide vs. fentanyl/nitrous oxideET
Time to commands
Aldrete score
No statistical difference
Talke et al, 2002 [13]Propofol vs. isoflurane vs. propofol/isofluraneET
TEO
Aldrete score
VAS
No statistical differences
Magni et al, 2005 [14]Sevoflurane/fentanyl vs. propofol/remifentanilET
SOMCT
No statistical differences
Citerio et al, 2012 [23]Sevoflurane/fentanyl vs. sevoflurane/remifentanil vs. propofol/remifentanilAldrete scoreNo statistical difference
Bhagat et al, 2008 [16]At time of dural closure bolus of propofol vs. fentanyl vs. isofluraneTime to emergence (dressing completion to extubation)
Early emergence (< 15 min)
GCS
Propofol > isoflurane > fentanyl 6 min > 5 min > 4 min (P = 0.0008) - not clinically significant
No statistical difference
Sneyd et al, 2005 [17]Propofol/remifentanil vs. sevoflurane/remifentanilET
TEO
Obey commands
No clinical differences

 

Table 3. Early Postoperative Recovery and Effects of Different Types of Intravenous Opioids [7, 10, 18-23, 30]
 
StudiesDrugsClinical variablesResults
ET: extubation time; GCS: Glasgow coma scale; SOMCT: short orientation memory concentration test.
Guy et al, 1997 [10]Remifentanil vs. fentanylET
Quality of recovery
No statistical difference
Low recovery score within 60 min more in fentanyl group
Naloxone use more in fentanyl group
Citerio et al, 2012 [23]Sevoflurane/remifentanil vs. sevoflurane/fentanyl vs. propofol/remifentanilAldrete scoreNo statistical difference
Gerlach et al, 2003 [18]Remifentanil/propofol vs. sufentanil IV pushes/propofolETRemifentanil group had earlier ET 6.4 min vs. 14.3 min (P = 0.003)
Balakrishnan et al, 2000 [19]Remifentanil vs. fentanylET (P = 0.04)
Obay commands (P < 0.001)
ET (P = 0.04)
Recovery in 10 min (P = 0.005)
Recovery in 20 min
Better in remifentanil group
No statistical difference
Van der Zwan et al, 2005 [22]Remifentanil/piritramide vs. fentanylGCS
Aldrete score
No statistical difference
Del Gaudio et al, 2006 [7]Remifentanil vs. fentanylET
Obey commands
Orientationx3
Aldrete score
Remifentanil group faster (P < 0.001)
Djian et al, 2006 [20]Remifentanil vs. sufentanilETNo statistical difference
Bilotta et al, 2007 [21]Remifentanil vs. sufentanilET
SOMCT
No statistical difference
Higher in remifentanil group (P < 0.0001)
From et al, 1990 [30]Alfentanil vs. fentanyl vs. sufentanilAlertnessMore in alfentanil group

 

Table 4. Studies Addressing Postoperative Hemodynamic Recovery [7, 10-14, 16, 17, 19, 20, 24, 30, 38]
 
StudiesDrugsClinical variableResults
Lauta et al, 2010 [11]Sevoflurane/remifentanil vs. propofol/remifentanilHR
MAP
No statistical difference
Sevo/Remi - more hypotension episodes (P = 0.0167)
Ravussin et al, 1991 [24]Thiopental/isoflurane vs. propofolHR, MAP
CPP
No statistical difference
Lower in propofol group
Todd et al, 1993 [12]Propofol/fentanyl vs. isoflurane/nitrous oxide vs. fentanyl/nitrous oxideICP
MAP
HR
Iso/N2O - higher ICP, HR, lower MAP
The difference is not statistically significant
Guy et al, 1997 [10]Remifentanil vs. fentanylSBP
ICP, CPP
Higher in fentanyl group P = 0.004
No statistical difference
Talke et al, 2002 [13]Propofol vs. isoflurane vs. propofol/isofluraneBP, HRNo statistical difference
Magni et al, 2005 [14]Sevoflurane/fentanyl vs. propofol/remifentanilMAP: intraoperative hypotension; postoperative HTN
HR
Remifentanil group had more hypotension intraoperative (P = 0.002), hypertension postoperative (P = 0.0046)
No statistical difference
Bhagat et al, 2008 [16]Propofol vs. fentanyl vs. isofluraneLess esmolol use with fentanyl P = 0.001
Sneyd et al, 2005 [17]Remifentanil/propofol vs. remifentanil/sevofluraneMAPRemi/Sevo - more hypotension episodes (P = 0.053)
Balakrishnan et al, 2000 [19]Remifentanil vs. fentanylHR, MAPNo statistical difference
Del Gaudio et al, 2006 [7]Remifentanil vs. fentanylHR, MAPNo statistical difference
Djian et al, 2006 [20]Remifentanil vs. sufentanilMAP
HR
Remifentanil P = 0.037 better MAP, HR stability
From et al, 1990 [30]Alfentanil vs. fentanyl vs. sufentanilRR
PH
Lower after extubation in Sufentanil group
Warner, 1996 [38]Alfentanil vs. remifentanilICP
MAP decrease
No statistical difference

 

Table 5. Summary of Studies Addressing Postoperative Pain [10, 11, 13, 18, 20, 22]
 
StudiesDrugsClinical variable - pain
Lauta et al, 2010 [11]Sevoflurane/remifentanil vs. propofol/remifentanilNo statistical difference
Guy et al, 1997 [10]Remifentanil vs. fentanylNo statistical difference
Talke et al, 2002 [13]Propofol vs. isoflurane vs. propofol/isofluraneNo statistical difference
Gerlach et al, 2003 [18]Remifentanil/propofol vs. sufentanil/propofolNo statistical difference
Van der Zwan et al, 2005 [22]Remifentanil/piritramide vs. fentanylRemifentanil - more pain postoperatively
Not statistically significant
Djian et al, 2006 [20]Remifentanil vs. sufentanilRemifentanil - greater use of morphine postoperatively (P = 0.016)