J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 7, Number 5, May 2015, pages 297-302

Small Vessel Disease/White Matter Disease of the Brain and Its Association With Osteoporosis

Tables

**Table 1.** Baseline Characteristics of the Study Variables
Factor	Osteoporosis present (n = 188)	Osteoporosis absent (n = 317)	P value
P values indicate the statistical significance between the presence and absence of WMD and the factors (per Chi-square analysis). BMI: body mass index.
Age
> 80 years	75 (39.9%)	180 (56.8%)	< 0.001
≤ 80 years	113 (60.1%)	137 (43.2%)
Sex
Females	171 (90.1%)	155 (48.8%)	< 0.001
Males	17 (9.1%)	162 (51.1%)
BMI (kg/m²)
≥ 26	83 (48.8%)	180 (61.0%)	< 0.01
Smoking
Non-smoker	120 (64.5%)	139 (45.1%)	< 0.01
Past or current smoker	66 (35.5%)	169 (54.8%)
Alcoholism	88 (47.6%)	164 (53.1%)	0.27
Diabetes Mellitus	35 (9.9%)	68 (21.5 %)	0.49
Hypertension	136 (72.3%)	220 (69.4%)	0.55
Hyperlipidemia	77 (40.9%)	168 (52.2%)	< 0.01
Coronary artery disease	28 (14.9%)	87 (27.4%)	< 0.01
Peripheral vascular disease	2 (1.1%)	11 (3.5%)	0.15
Atrial fibrillation	25 (13.3%)	43 (13.6%)	1.00
Heart failure	12 (6.4%)	19 (5.9%)	0.85
Renal failure	14 (7.4%)	23 (7.3%)	1.00
White matter disease prevalence	137 (72.9%)	198 (62.5%)	0.02
White matter disease severity	6.19 (SD 4.74)	4.37 (SD 4.09)	< 0.01

**Table 2.** Logistic Regression Analysis: Global White Matter Disease Score and Its Association With Osteoporosis
Model	Odds ratio	95% confidence interval	P-value
White matter disease score was considered as a continuous variable.
Global white matter disease alone	1.10	1.05 - 1.14	< 0.001
Corrected for age and sex	1.10	1.04 - 1.15	< 0.001
Corrected for age, sex and vascular risk factors	1.11	1.05 - 1.18	< 0.001