J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 7, Number 4, April 2015, pages 232-241

Comparative Changes in Tissue Oxygenation Between Laparoscopic and Open Cholecystectomy

Figure 1. Mean percentage (%) changes in ((A-a)DO₂) parameter, determined from preoperative level, in the across time measurements between laparoscopic and open cholecystectomy group.

Figure 2. Mean percentage (%) changes in PaCO₂ parameter, determined from preoperative level, in the across time measurements between laparoscopic and open cholecystectomy group.

**Table 1.** Studied ABGs-Related Parameters for the Laparoscopic Cholecystectomy Group
Studied parameters	Preoperative value mean ± SD	Second postoperative day value mean ± SD	Changes from preoperative to second postoperative day mean ± SEM (95% CI), %	Eighth postoperative day value mean ± SD	Changes from preoperative to eighth postoperative day mean ± SEM (95% CI), %
*Values in pH, PaO₂ mm Hg and PaCO₂ mm Hg have been numerically reported in a previous work [18].
(A-a)DO₂, kPa (mm Hg)	3.428 ± 1.458 (25.71 ± 10.94)	3.773 ± 1.357 (28.30 ± 10.18)	44.0493 ± 32.6119 (-26.404, 114.503)	2.781 ± 1.296 (20.86 ± 9.72)	4.3974 ± 22.1251 (-43.401, 52.196)
HCO₃^-, mEq/L	24.14 ± 1.10	25.09 ± 2.11	6.445 ± 0.697 (1.30, 11.59)	24.47 ± 1.45	3.474 ± 1.001 (-3.22, 10.17)
SaO₂%	94.93 ± 2.11	94.93 ± 1.83	-0.2357 ± 0.2087 (-1.778, 1.307)	95.82 ± 2.47	1.097 ± 0.5786 (-2.773, 4.967)
Oct in vol%	17.55 ± 1.90	15.69 ± 1.88	-10.71 ± 1.34 (-20.62, -0.80)	15.98 ± 1.73	-7.095 ± 1.632 (-18.01, 3.82)
pH	7.41 ± 0.03	7.43 ± 0.03	0.2747 ± 0.1072 (0.044, 0.507)	7.43 ± 0.03	0.1825 ± 0.1348 (-0.109, 0.474)
PaO₂, kPa (mm Hg)	10.521 ± 2.322 (78.91 ± 17.42)	9.988 ± 1.586 (74.71 ± 11.90)	- 3.6965 ± 3.4823 (-11.219, 3.827)	10.96 ± 1.492 (82.20 ± 11.19)	7.7561 ± 6.4765 (-6.236, 21.748)
PaCO₂, kPa (mm Hg)	5.112 ± 0.308 (38.34 ± 2.31)	4.984 ± 0.413 (37.38 ± 3.10)	- 2.3400 ± 2.2046 (-7.103, 2.423)	4.94 ± 0.370 (37.05 ± 2.78)	- 3.1716 ± 2.0601 (-7.622, 1.279)

Table 1. Studied ABGs-Related Parameters for the Laparoscopic Cholecystectomy Group

Studied parameters

Preoperative value mean ± SD

Second postoperative day value mean ± SD

Changes from preoperative to second postoperative day mean ± SEM (95% CI), %

Eighth postoperative day value mean ± SD

Changes from preoperative to eighth postoperative day mean ± SEM (95% CI), %

*Values in pH, PaO₂ mm Hg and PaCO₂ mm Hg have been numerically reported in a previous work [18].

(A-a)DO₂, kPa (mm Hg)

3.428 ± 1.458 (25.71 ± 10.94)

3.773 ± 1.357 (28.30 ± 10.18)

44.0493 ± 32.6119 (-26.404, 114.503)

2.781 ± 1.296 (20.86 ± 9.72)

4.3974 ± 22.1251 (-43.401, 52.196)

HCO₃^-, mEq/L

24.14 ± 1.10

25.09 ± 2.11

6.445 ± 0.697 (1.30, 11.59)

24.47 ± 1.45

3.474 ± 1.001 (-3.22, 10.17)

SaO₂%

94.93 ± 2.11

94.93 ± 1.83

-0.2357 ± 0.2087 (-1.778, 1.307)

95.82 ± 2.47

1.097 ± 0.5786 (-2.773, 4.967)

Oct in vol%

17.55 ± 1.90

15.69 ± 1.88

-10.71 ± 1.34 (-20.62, -0.80)

15.98 ± 1.73

-7.095 ± 1.632 (-18.01, 3.82)

7.41 ± 0.03

7.43 ± 0.03

0.2747 ± 0.1072 (0.044, 0.507)

7.43 ± 0.03

0.1825 ± 0.1348 (-0.109, 0.474)

PaO₂, kPa (mm Hg)

10.521 ± 2.322 (78.91 ± 17.42)

9.988 ± 1.586 (74.71 ± 11.90)

- 3.6965 ± 3.4823 (-11.219, 3.827)

10.96 ± 1.492 (82.20 ± 11.19)

7.7561 ± 6.4765 (-6.236, 21.748)

PaCO₂, kPa (mm Hg)

5.112 ± 0.308 (38.34 ± 2.31)

4.984 ± 0.413 (37.38 ± 3.10)

- 2.3400 ± 2.2046 (-7.103, 2.423)

4.94 ± 0.370 (37.05 ± 2.78)

- 3.1716 ± 2.0601 (-7.622, 1.279)

**Table 2.** Studied ABGs-Related Parameters for the Open Cholecystectomy Group
Studied parameters	Preoperative value mean ± SD	Second postoperative day value mean ± SD	Changes from preoperative to second postoperative day mean ± SEM (95% CI), %	Eighth postoperative day value mean ± SD	Changes from preoperative to eighth postoperative day mean ± SEM (95% CI), %
*Values in pH, PaO₂ mm Hg and PaCO₂ mm Hg have been numerically reported in a previous work [18].
(A-a)DO₂, kPa (mm Hg)	3.776 ± 1.949 (28.32 ± 14.62)	4.673 ± 0.966 (35.05 ± 7.25)	148.1581 ± 123.4195 (-131.04, 427.35)	2.857 ± 1.556 (21.43 ± 11.67)	17.5287 ± 36.7968 (-65.71, 100.77)
HCO₃^-, mEq/L	24.19 ± 3.97	25.71 ± 1.72	8.159 ± 3.151 (-12.92, 29.23)	25.01 ± 1.19	8.540 ± 3.343 (-13.10, 30.18)
SaO₂%	95.34 ± 2.19	93.6 ± 1.41	-1.8307 ± 0.1626 (-2.918, -0.7433)	94.99 ± 2.66	-0.2117 ± 0.5607 (-3.8415, 3.4179)
Oct in vol%	16.99 ± 2.37	14.62 ± 2.23	-11.31 ± 2.318 (-26.81, 4.19)	16.10 ± 2.38	0.248 ± 3.109 (-19.88, 20.37)
pH	7.44 ± 0.02	7.44 ± 0.03	0.07508 ± 0.1091 (-0.171, 0.323)	7.42 ± 0.03	-0.1938 ± 0.1207 (-0.466, 0.080)
PaO₂, kPa (mm Hg)	10.244 ± 2.025 (76.83 ± 15.19)	9.086 ± 1.004 (68.15 ± 7.53)	- 8.9566 ± 5.4844 (-21.363, 3.450)	10.5 ± 1.617 (78.75 ± 12.13)	6.4946 ± 8.3616 (12.421, 25.410)
PaCO₂, kPa (mm Hg)	4.921 ± 0.785 (36.91 ± 5.89)	5.094 ± 0.337 (38.21 ± 2.53)	5.9747 ± 6.1044 (-7.834, 19.784)	5.252 ± 0.332 (39.39 ±2.49)	9.4777 ± 6.8491 (-6.016, 24.971)

Table 2. Studied ABGs-Related Parameters for the Open Cholecystectomy Group

Studied parameters

Preoperative value mean ± SD

Second postoperative day value mean ± SD

Changes from preoperative to second postoperative day mean ± SEM (95% CI), %

Eighth postoperative day value mean ± SD

Changes from preoperative to eighth postoperative day mean ± SEM (95% CI), %

*Values in pH, PaO₂ mm Hg and PaCO₂ mm Hg have been numerically reported in a previous work [18].

(A-a)DO₂, kPa (mm Hg)

3.776 ± 1.949 (28.32 ± 14.62)

4.673 ± 0.966 (35.05 ± 7.25)

148.1581 ± 123.4195 (-131.04, 427.35)

2.857 ± 1.556 (21.43 ± 11.67)

17.5287 ± 36.7968 (-65.71, 100.77)

HCO₃^-, mEq/L

24.19 ± 3.97

25.71 ± 1.72

8.159 ± 3.151 (-12.92, 29.23)

25.01 ± 1.19

8.540 ± 3.343 (-13.10, 30.18)

SaO₂%

95.34 ± 2.19

93.6 ± 1.41

-1.8307 ± 0.1626 (-2.918, -0.7433)

94.99 ± 2.66

-0.2117 ± 0.5607 (-3.8415, 3.4179)

Oct in vol%

16.99 ± 2.37

14.62 ± 2.23

-11.31 ± 2.318 (-26.81, 4.19)

16.10 ± 2.38

0.248 ± 3.109 (-19.88, 20.37)

7.44 ± 0.02

7.44 ± 0.03

0.07508 ± 0.1091 (-0.171, 0.323)

7.42 ± 0.03

-0.1938 ± 0.1207 (-0.466, 0.080)

PaO₂, kPa (mm Hg)

10.244 ± 2.025 (76.83 ± 15.19)

9.086 ± 1.004 (68.15 ± 7.53)

- 8.9566 ± 5.4844 (-21.363, 3.450)

10.5 ± 1.617 (78.75 ± 12.13)

6.4946 ± 8.3616 (12.421, 25.410)

PaCO₂, kPa (mm Hg)

4.921 ± 0.785 (36.91 ± 5.89)

5.094 ± 0.337 (38.21 ± 2.53)

5.9747 ± 6.1044 (-7.834, 19.784)

5.252 ± 0.332 (39.39 ±2.49)

9.4777 ± 6.8491 (-6.016, 24.971)