Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 7, Number 1, January 2015, pages 41-44

Hyaluronic Acid Concentration in Pleural Fluid: Diagnostic Aid for Tuberculous Pleurisy

Figure

Figure 1.
Figure 1. Receiver operating characteristic curves for pleural fluid adenosine deaminase (ADA) and hyaluronic acid (HA) in patients with tuberculous pleurisy.

Tables

Table 1. Clinical Data for Pleurisy Patients Included in the Study Population
 
All (n = 27)Tuberculosis (n = 10)Non-tuberculosis (n = 17)P
Chronic respiratory diseases: COPD, bronchial asthma and interstitial pneumonia; chronic cardiovascular diseases: congestive heart failure and ventricular dysfunction; chronic kidney diseases: undergoing hemodialysis and after renal transplantation; HA: hyaluronic acid, ADA: adenosine deaminase, LDH: lactate dehydrogenase.
Gender (male)21 (77.8%)8 (80.0%)13 (76.5%)1.00
Age (years)70.1 ± 19.157.1 ± 20.679.7 ± 11.50.032
Comorbidity
  Liver cirrhosis5 (18.5%)1 (10.0%)4 (23.5%)0.621
  Diabetes mellitus8 (29.6%)3 (30.0%)5 (29.4%)1.00
  Chronic respiratory diseases2 (7.41%)1 (10.0%)1 (5.88%)1.00
  Chronic heart diseases7 (25.9%)2 (20.0%)5 (29.4%)0.678
  Chronic kidney diseases4 (14.8%)1 (10.0%)3 (17.6%)1.00
Clinical status at disease onset
  SOFA score2.72 ± 1.781.67 ± 0.823.25 ± 1.910.073
  White blood cell counts (blood test)12.4 ± 8.1914.0 ± 9.119.22 ± 5.250.256
  C-reactive protein9.30 ± 7.095.90 ± 2.5511.0 ± 8.080.156
Pleural effusion test
  HA (× 103 ng/mL)26.5 ± 23.542.9 ± 23.316.8 ± 17.90.003
  ADA (IU/L)79.8 ± 74.389.7 ± 33.374.0 ± 90.90.032
  LDH (× 102 IU/L)50.5 ± 1288.46 ± 4.6575.2 ± 1570.195

 

Table 2. The Optimal Cut-Off Level for Hyaluronic Acid and Adenosine Deaminase Concentrations in the Pleural Fluid of Patients With Tuberculous Pleurisy
 
Cut-offSensitivitySpecificityPPVNPVLikelihood ratioOdds ratio
HA: hyaluronic acid; ADA: adenosine deaminase; PPV: positive predictive value; NPV: negative predictive value.
HA24,950 ng/mL0.800000.882350.800000.882356.830.0
ADA51.9 IU/L0.900000.647060.600000.916672.5516.5